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Grey and white matter correlates of recent and remote autobiographical memory retrieval--insights from the dementias.

Irish M, Hornberger M, El Wahsh S, Lam BY, Lah S, Miller L, Hsieh S, Hodges JR, Piguet O - PLoS ONE (2014)

Bottom Line: All patient groups displayed significant remote memory impairments relative to Controls.The integrity of the anterior temporal cortices was related to the retrieval of remote memories, whereas the posterior cingulate cortex emerged as a structure significantly associated with recent autobiographical memory retrieval.Our findings demonstrate the importance of core brain structures, including the medial prefrontal cortex and hippocampus, irrespective of time period, and point towards the contribution of discrete regions in mediating successful retrieval of distant versus recently experienced events.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, the University of New South Wales, Sydney, Australia; Neuroscience Research Australia, Randwick, Sydney, Australia; Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, Australia.

ABSTRACT
The capacity to remember self-referential past events relies on the integrity of a distributed neural network. Controversy exists, however, regarding the involvement of specific brain structures for the retrieval of recently experienced versus more distant events. Here, we explored how characteristic patterns of atrophy in neurodegenerative disorders differentially disrupt remote versus recent autobiographical memory. Eleven behavioural-variant frontotemporal dementia, 10 semantic dementia, 15 Alzheimer's disease patients and 14 healthy older Controls completed the Autobiographical Interview. All patient groups displayed significant remote memory impairments relative to Controls. Similarly, recent period retrieval was significantly compromised in behavioural-variant frontotemporal dementia and Alzheimer's disease, yet semantic dementia patients scored in line with Controls. Voxel-based morphometry and diffusion tensor imaging analyses, for all participants combined, were conducted to investigate grey and white matter correlates of remote and recent autobiographical memory retrieval. Neural correlates common to both recent and remote time periods were identified, including the hippocampus, medial prefrontal, and frontopolar cortices, and the forceps minor and left hippocampal portion of the cingulum bundle. Regions exclusively implicated in each time period were also identified. The integrity of the anterior temporal cortices was related to the retrieval of remote memories, whereas the posterior cingulate cortex emerged as a structure significantly associated with recent autobiographical memory retrieval. This study represents the first investigation of the grey and white matter correlates of remote and recent autobiographical memory retrieval in neurodegenerative disorders. Our findings demonstrate the importance of core brain structures, including the medial prefrontal cortex and hippocampus, irrespective of time period, and point towards the contribution of discrete regions in mediating successful retrieval of distant versus recently experienced events.

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Relationship between fractional anisotropy (FA) values in white matter tracts of interest and recent memory.All participants included in the analyses (n = 49). Age is included as a covariate in the analyses. Plotted data depict a positive association between fractional anisotropy values and memory performance, with the magnitude of this relationship calculated using Pearson's R correlations (r).
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pone-0113081-g005: Relationship between fractional anisotropy (FA) values in white matter tracts of interest and recent memory.All participants included in the analyses (n = 49). Age is included as a covariate in the analyses. Plotted data depict a positive association between fractional anisotropy values and memory performance, with the magnitude of this relationship calculated using Pearson's R correlations (r).

Mentions: Fractional anisotropy values in the left uncinate fasciculus (r = .449, p = .001), left cingulum (corpus callosum part: r = .340, p = .008; hippocampal part: r = .399, p = .002), and the forceps minor (r = .440, p = .001) were found to correlate significantly with remote ABM retrieval (Figure 4). In contrast, only fractional anisotropy values in the forceps minor (r = .417, p = .001) and the left cingulum (hippocampal part; r = .330, p = .010) were significantly associated with recent ABM performance (Figure 5).


Grey and white matter correlates of recent and remote autobiographical memory retrieval--insights from the dementias.

Irish M, Hornberger M, El Wahsh S, Lam BY, Lah S, Miller L, Hsieh S, Hodges JR, Piguet O - PLoS ONE (2014)

Relationship between fractional anisotropy (FA) values in white matter tracts of interest and recent memory.All participants included in the analyses (n = 49). Age is included as a covariate in the analyses. Plotted data depict a positive association between fractional anisotropy values and memory performance, with the magnitude of this relationship calculated using Pearson's R correlations (r).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232597&req=5

pone-0113081-g005: Relationship between fractional anisotropy (FA) values in white matter tracts of interest and recent memory.All participants included in the analyses (n = 49). Age is included as a covariate in the analyses. Plotted data depict a positive association between fractional anisotropy values and memory performance, with the magnitude of this relationship calculated using Pearson's R correlations (r).
Mentions: Fractional anisotropy values in the left uncinate fasciculus (r = .449, p = .001), left cingulum (corpus callosum part: r = .340, p = .008; hippocampal part: r = .399, p = .002), and the forceps minor (r = .440, p = .001) were found to correlate significantly with remote ABM retrieval (Figure 4). In contrast, only fractional anisotropy values in the forceps minor (r = .417, p = .001) and the left cingulum (hippocampal part; r = .330, p = .010) were significantly associated with recent ABM performance (Figure 5).

Bottom Line: All patient groups displayed significant remote memory impairments relative to Controls.The integrity of the anterior temporal cortices was related to the retrieval of remote memories, whereas the posterior cingulate cortex emerged as a structure significantly associated with recent autobiographical memory retrieval.Our findings demonstrate the importance of core brain structures, including the medial prefrontal cortex and hippocampus, irrespective of time period, and point towards the contribution of discrete regions in mediating successful retrieval of distant versus recently experienced events.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, the University of New South Wales, Sydney, Australia; Neuroscience Research Australia, Randwick, Sydney, Australia; Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, Australia.

ABSTRACT
The capacity to remember self-referential past events relies on the integrity of a distributed neural network. Controversy exists, however, regarding the involvement of specific brain structures for the retrieval of recently experienced versus more distant events. Here, we explored how characteristic patterns of atrophy in neurodegenerative disorders differentially disrupt remote versus recent autobiographical memory. Eleven behavioural-variant frontotemporal dementia, 10 semantic dementia, 15 Alzheimer's disease patients and 14 healthy older Controls completed the Autobiographical Interview. All patient groups displayed significant remote memory impairments relative to Controls. Similarly, recent period retrieval was significantly compromised in behavioural-variant frontotemporal dementia and Alzheimer's disease, yet semantic dementia patients scored in line with Controls. Voxel-based morphometry and diffusion tensor imaging analyses, for all participants combined, were conducted to investigate grey and white matter correlates of remote and recent autobiographical memory retrieval. Neural correlates common to both recent and remote time periods were identified, including the hippocampus, medial prefrontal, and frontopolar cortices, and the forceps minor and left hippocampal portion of the cingulum bundle. Regions exclusively implicated in each time period were also identified. The integrity of the anterior temporal cortices was related to the retrieval of remote memories, whereas the posterior cingulate cortex emerged as a structure significantly associated with recent autobiographical memory retrieval. This study represents the first investigation of the grey and white matter correlates of remote and recent autobiographical memory retrieval in neurodegenerative disorders. Our findings demonstrate the importance of core brain structures, including the medial prefrontal cortex and hippocampus, irrespective of time period, and point towards the contribution of discrete regions in mediating successful retrieval of distant versus recently experienced events.

Show MeSH
Related in: MedlinePlus