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Finding needles in a haystack: application of network analysis and target enrichment studies for the identification of potential anti-diabetic phytochemicals.

Fayaz SM, Suvanish Kumar VS, Rajanikant KG - PLoS ONE (2014)

Bottom Line: Herbal medicines have been proven to be effective anti-diabetic agents compared to synthetic drugs in terms of side effects.This study also involves a focused and constructive strategy for preparing new effective anti-diabetic formulations.Therefore, the successive use of network analysis combined with target enrichment studies would accelerate the discovery of potential anti-diabetic phytochemicals.

View Article: PubMed Central - PubMed

Affiliation: School of Biotechnology, National Institute of Technology Calicut, Calicut 673601, India.

ABSTRACT
Diabetes mellitus is a debilitating metabolic disorder and remains a significant threat to public health. Herbal medicines have been proven to be effective anti-diabetic agents compared to synthetic drugs in terms of side effects. However, the complexity in their chemical constituents and mechanism of action, hinder the effort to discover novel anti-diabetic drugs. Hence, understanding the biological and chemical basis of pharmacological action of phytochemicals is essential for the discovery of potential anti-diabetic drugs. Identifying important active compounds, their protein targets and the pathways involved in diabetes would serve this purpose. In this context, the present study was aimed at exploring the mechanism of action of anti-diabetic plants phytochemicals through network and chemical-based approaches. This study also involves a focused and constructive strategy for preparing new effective anti-diabetic formulations. Further, a protocol for target enrichment was proposed, to identify novel protein targets for important active compounds. Therefore, the successive use of network analysis combined with target enrichment studies would accelerate the discovery of potential anti-diabetic phytochemicals.

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Network containing various diseases in which the protein targets are involved.
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pone-0112911-g005: Network containing various diseases in which the protein targets are involved.

Mentions: The data regarding different diseases in which the diabetes-related protein targets are involved was collected and a network was drawn from it (Figure 5). Here it can be seen that most of the proteins involved in diabetes are also involved in cancer. Diabetes and cancer are two heterogeneous, multifactorial, severe, and chronic diseases. Numerous studies have shown a contiguous association between diabetes and cancer. The American Diabetes Association and the American Cancer Society jointly stated that cancer incidence is associated with diabetes as well as certain diabetes risk factors and diabetes treatments [16]. The association between diabetes and cancer incidence or prognosis and existence of risk factors common to both the diseases has been reported [16]. Further, epidemiological studies have indicated that the risk of several types of cancer (including pancreas, liver, breast, colorectal, urinary tract, and female reproductive organs) has increased in diabetic patients [17].


Finding needles in a haystack: application of network analysis and target enrichment studies for the identification of potential anti-diabetic phytochemicals.

Fayaz SM, Suvanish Kumar VS, Rajanikant KG - PLoS ONE (2014)

Network containing various diseases in which the protein targets are involved.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232558&req=5

pone-0112911-g005: Network containing various diseases in which the protein targets are involved.
Mentions: The data regarding different diseases in which the diabetes-related protein targets are involved was collected and a network was drawn from it (Figure 5). Here it can be seen that most of the proteins involved in diabetes are also involved in cancer. Diabetes and cancer are two heterogeneous, multifactorial, severe, and chronic diseases. Numerous studies have shown a contiguous association between diabetes and cancer. The American Diabetes Association and the American Cancer Society jointly stated that cancer incidence is associated with diabetes as well as certain diabetes risk factors and diabetes treatments [16]. The association between diabetes and cancer incidence or prognosis and existence of risk factors common to both the diseases has been reported [16]. Further, epidemiological studies have indicated that the risk of several types of cancer (including pancreas, liver, breast, colorectal, urinary tract, and female reproductive organs) has increased in diabetic patients [17].

Bottom Line: Herbal medicines have been proven to be effective anti-diabetic agents compared to synthetic drugs in terms of side effects.This study also involves a focused and constructive strategy for preparing new effective anti-diabetic formulations.Therefore, the successive use of network analysis combined with target enrichment studies would accelerate the discovery of potential anti-diabetic phytochemicals.

View Article: PubMed Central - PubMed

Affiliation: School of Biotechnology, National Institute of Technology Calicut, Calicut 673601, India.

ABSTRACT
Diabetes mellitus is a debilitating metabolic disorder and remains a significant threat to public health. Herbal medicines have been proven to be effective anti-diabetic agents compared to synthetic drugs in terms of side effects. However, the complexity in their chemical constituents and mechanism of action, hinder the effort to discover novel anti-diabetic drugs. Hence, understanding the biological and chemical basis of pharmacological action of phytochemicals is essential for the discovery of potential anti-diabetic drugs. Identifying important active compounds, their protein targets and the pathways involved in diabetes would serve this purpose. In this context, the present study was aimed at exploring the mechanism of action of anti-diabetic plants phytochemicals through network and chemical-based approaches. This study also involves a focused and constructive strategy for preparing new effective anti-diabetic formulations. Further, a protocol for target enrichment was proposed, to identify novel protein targets for important active compounds. Therefore, the successive use of network analysis combined with target enrichment studies would accelerate the discovery of potential anti-diabetic phytochemicals.

Show MeSH
Related in: MedlinePlus