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Correlation between renal function and common risk factors for chronic kidney disease in a healthy middle-aged population: a prospective observational 2-year study.

Ohno M, Deguchi F, Izumi K, Ishigaki H, Sarui H, Sasaki A, Segawa T, Yamaki T, Kojima T, Ohashi H - PLoS ONE (2014)

Bottom Line: Over 2 years, eGFR showed a significant decrease.Univariate regression analysis revealed that changes in fasting plasma glucose (FPG), total cholesterol, LDL-cholesterol, serum uric acid levels, and hemoglobin showed a significant negative correlation with changes in eGFR.Multiple regression analysis confirmed that changes in FPG, serum uric acid levels, in particular, and hemoglobin had a significant negative correlation with changes in eGFR.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Murakami Memorial Hospital, Asahi University School of Dentistry, Gifu City, Gifu, Japan.

ABSTRACT

Background/aims: Age, proteinuria, metabolic syndrome, and hyperuricemia are the reported risk factors for chronic kidney disease (CKD) and cardiovascular disease (CVD). However, the best predictor of changes in renal function in the early stages of renal disease in a healthy middle-aged population is still unknown. Our study evaluated the correlation between changes in renal function and common risk factors to determine such a predictor.

Methods: In total, 2,853 healthy persons aged ≤50 years participated in the study. They had no proteinuria and were not on medications for hypertension, diabetes mellitus, hyperlipidemia, or hyperuricemia. Over 2 years, participants underwent annual health screening. The relationship between changes in estimated glomerular filtration rate (eGFR) and changes in risk factors for CKD was evaluated using univariate and multivariate linear regression analyses.

Results: Over 2 years, eGFR showed a significant decrease. Univariate regression analysis revealed that changes in fasting plasma glucose (FPG), total cholesterol, LDL-cholesterol, serum uric acid levels, and hemoglobin showed a significant negative correlation with changes in eGFR. Multiple regression analysis confirmed that changes in FPG, serum uric acid levels, in particular, and hemoglobin had a significant negative correlation with changes in eGFR.

Conclusion: The changes in eGFR and other variables over 2 years were small and could be within expected biologic variation. A longer observational study is needed to elucidate whether FPG, serum uric acid and hemoglobin represent the earliest markers of eGFR decline.

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Related in: MedlinePlus

Disposition of the study population.
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pone-0113263-g001: Disposition of the study population.

Mentions: During 2-year follow-up, all except 81 subjects were assessed annually (Figure 1). No subject developed proteinuria or had to be started on medications for hypertension, diabetes, hyperlipidemia, or hyperuricemia.


Correlation between renal function and common risk factors for chronic kidney disease in a healthy middle-aged population: a prospective observational 2-year study.

Ohno M, Deguchi F, Izumi K, Ishigaki H, Sarui H, Sasaki A, Segawa T, Yamaki T, Kojima T, Ohashi H - PLoS ONE (2014)

Disposition of the study population.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232529&req=5

pone-0113263-g001: Disposition of the study population.
Mentions: During 2-year follow-up, all except 81 subjects were assessed annually (Figure 1). No subject developed proteinuria or had to be started on medications for hypertension, diabetes, hyperlipidemia, or hyperuricemia.

Bottom Line: Over 2 years, eGFR showed a significant decrease.Univariate regression analysis revealed that changes in fasting plasma glucose (FPG), total cholesterol, LDL-cholesterol, serum uric acid levels, and hemoglobin showed a significant negative correlation with changes in eGFR.Multiple regression analysis confirmed that changes in FPG, serum uric acid levels, in particular, and hemoglobin had a significant negative correlation with changes in eGFR.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Murakami Memorial Hospital, Asahi University School of Dentistry, Gifu City, Gifu, Japan.

ABSTRACT

Background/aims: Age, proteinuria, metabolic syndrome, and hyperuricemia are the reported risk factors for chronic kidney disease (CKD) and cardiovascular disease (CVD). However, the best predictor of changes in renal function in the early stages of renal disease in a healthy middle-aged population is still unknown. Our study evaluated the correlation between changes in renal function and common risk factors to determine such a predictor.

Methods: In total, 2,853 healthy persons aged ≤50 years participated in the study. They had no proteinuria and were not on medications for hypertension, diabetes mellitus, hyperlipidemia, or hyperuricemia. Over 2 years, participants underwent annual health screening. The relationship between changes in estimated glomerular filtration rate (eGFR) and changes in risk factors for CKD was evaluated using univariate and multivariate linear regression analyses.

Results: Over 2 years, eGFR showed a significant decrease. Univariate regression analysis revealed that changes in fasting plasma glucose (FPG), total cholesterol, LDL-cholesterol, serum uric acid levels, and hemoglobin showed a significant negative correlation with changes in eGFR. Multiple regression analysis confirmed that changes in FPG, serum uric acid levels, in particular, and hemoglobin had a significant negative correlation with changes in eGFR.

Conclusion: The changes in eGFR and other variables over 2 years were small and could be within expected biologic variation. A longer observational study is needed to elucidate whether FPG, serum uric acid and hemoglobin represent the earliest markers of eGFR decline.

Show MeSH
Related in: MedlinePlus