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Decision tree analysis of traditional risk factors of carotid atherosclerosis and a cutpoint-based prevention strategy.

Qin G, Luo L, Lv L, Xiao Y, Tu J, Tao L, Wu J, Tang X, Pan W - PLoS ONE (2014)

Bottom Line: The statistical analysis showed significant differences in carotid atherosclerosis incidence between different genders (P<0.0001) and age groups (P<0.001).FPG (CP: 5.52 mmol/L) and TG (CP: 1.51 mmol/L) were the most important traditional risk factors for women between 20-40 and 41-59 years of age, respectively.Traditional risk factors and relevant cutpoints were not identical in different genders and age groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

ABSTRACT

Background: Reducing the exposure to risk factors for the prevention of cardio-cerebral vascular disease is a crucial issue. Few reports have described practical interventions for preventing cardiovascular disease in different genders and age groups, particularly detailed and specific cutpoint-based prevention strategies.

Methods: We collected the health examination data of 5822 subjects between 20 and 80 years of age. The administration of medical questionnaires and physical examinations and the measurement of blood pressure, fasting plasma glucose (FPG) and blood lipids [total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholesterol (LDL-C)] were performed by physicians. Carotid ultrasound was performed to examine the carotid intima-media thickness (CIMT), which was defined as carotid atherosclerosis when CIMT ≥0.9 mm. Decision tree analysis was used to screen for the most important risk factors for carotid atherosclerosis and to identify the relevant cutpoints.

Results: In the study population, the incidence of carotid atherosclerosis was 12.20% (men: 14.10%, women: 9.20%). The statistical analysis showed significant differences in carotid atherosclerosis incidence between different genders (P<0.0001) and age groups (P<0.001). The decision tree analysis showed that in men, the most important traditional risk factors for carotid atherosclerosis were TC (cutpoint [CP]: 6.31 mmol/L) between the ages of 20-40 and FPG (CP: 5.79 mmol/L) between the ages of 41-59. By comparison, LDL-C (CP: 4.27 mmol/L) became the major risk factor when FPG ≤5.79 mmol/L. FPG (CP: 5.52 mmol/L) and TG (CP: 1.51 mmol/L) were the most important traditional risk factors for women between 20-40 and 41-59 years of age, respectively.

Conclusion: Traditional risk factors and relevant cutpoints were not identical in different genders and age groups. A specific gender and age group-based cutpoint strategy might contribute to preventing cardiovascular disease.

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Related in: MedlinePlus

The assessment of traditional risk factors in men for carotid atherosclerosis in different age groups using decision tree analysis.
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pone-0111769-g002: The assessment of traditional risk factors in men for carotid atherosclerosis in different age groups using decision tree analysis.

Mentions: We used decision tree analysis to screen for the most important traditional risk factors for carotid atherosclerosis by gender and age groups. The results are presented in Figure 2 and Figure 3.


Decision tree analysis of traditional risk factors of carotid atherosclerosis and a cutpoint-based prevention strategy.

Qin G, Luo L, Lv L, Xiao Y, Tu J, Tao L, Wu J, Tang X, Pan W - PLoS ONE (2014)

The assessment of traditional risk factors in men for carotid atherosclerosis in different age groups using decision tree analysis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232379&req=5

pone-0111769-g002: The assessment of traditional risk factors in men for carotid atherosclerosis in different age groups using decision tree analysis.
Mentions: We used decision tree analysis to screen for the most important traditional risk factors for carotid atherosclerosis by gender and age groups. The results are presented in Figure 2 and Figure 3.

Bottom Line: The statistical analysis showed significant differences in carotid atherosclerosis incidence between different genders (P<0.0001) and age groups (P<0.001).FPG (CP: 5.52 mmol/L) and TG (CP: 1.51 mmol/L) were the most important traditional risk factors for women between 20-40 and 41-59 years of age, respectively.Traditional risk factors and relevant cutpoints were not identical in different genders and age groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

ABSTRACT

Background: Reducing the exposure to risk factors for the prevention of cardio-cerebral vascular disease is a crucial issue. Few reports have described practical interventions for preventing cardiovascular disease in different genders and age groups, particularly detailed and specific cutpoint-based prevention strategies.

Methods: We collected the health examination data of 5822 subjects between 20 and 80 years of age. The administration of medical questionnaires and physical examinations and the measurement of blood pressure, fasting plasma glucose (FPG) and blood lipids [total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholesterol (LDL-C)] were performed by physicians. Carotid ultrasound was performed to examine the carotid intima-media thickness (CIMT), which was defined as carotid atherosclerosis when CIMT ≥0.9 mm. Decision tree analysis was used to screen for the most important risk factors for carotid atherosclerosis and to identify the relevant cutpoints.

Results: In the study population, the incidence of carotid atherosclerosis was 12.20% (men: 14.10%, women: 9.20%). The statistical analysis showed significant differences in carotid atherosclerosis incidence between different genders (P<0.0001) and age groups (P<0.001). The decision tree analysis showed that in men, the most important traditional risk factors for carotid atherosclerosis were TC (cutpoint [CP]: 6.31 mmol/L) between the ages of 20-40 and FPG (CP: 5.79 mmol/L) between the ages of 41-59. By comparison, LDL-C (CP: 4.27 mmol/L) became the major risk factor when FPG ≤5.79 mmol/L. FPG (CP: 5.52 mmol/L) and TG (CP: 1.51 mmol/L) were the most important traditional risk factors for women between 20-40 and 41-59 years of age, respectively.

Conclusion: Traditional risk factors and relevant cutpoints were not identical in different genders and age groups. A specific gender and age group-based cutpoint strategy might contribute to preventing cardiovascular disease.

Show MeSH
Related in: MedlinePlus