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TSAT is a better predictor than ferritin of hemoglobin response to Epoetin alfa in US dialysis patients.

Gaweda AE, Bhat P, Maglinte GA, Chang CL, Hill J, Park GS, Ashfaq A, Gitlin M - Hemodial Int (2013)

Bottom Line: Transferrin saturation, but not ferritin, had a statistically significant (P < 0.05) modifying effect on Hb response.Maximum Hb response was achieved when TSAT was 34%, with minimal incremental effect beyond these levels.Long-term safety of iron use to improve Hb response to ESA warrants further study.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Medicine, University of Louisville, Louisville, Kentucky, USA.

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Related in: MedlinePlus

Relative hemoglobin (Hb) response from interval k to k‚ÄČ+‚ÄČ1 to a fixed-unit Epoetin alfa dose change from interval k‚ÄČ‚ąí‚ÄČ1 to k across transferrin saturation (TSAT) values, derived from the TSAT model. ESA‚ÄČ=‚ÄČerythropoiesis-stimulating agent.
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fig03: Relative hemoglobin (Hb) response from interval k to k‚ÄČ+‚ÄČ1 to a fixed-unit Epoetin alfa dose change from interval k‚ÄČ‚ąí‚ÄČ1 to k across transferrin saturation (TSAT) values, derived from the TSAT model. ESA‚ÄČ=‚ÄČerythropoiesis-stimulating agent.

Mentions: Figure‚ÄČ3 depicts the change in Hb response as a function of TSAT (Equation (1)). Maximum Hb response to ESA was reached at TSAT of 35%. As indicated by the increasing slope of the curve, increasing TSAT from 0% to 10% leads to a strong improvement in Hb response. Each subsequent increase in TSAT, from 10% to 20% and again from 20% to 30%, results in diminished improvement in Hb response by approximately one-half. Finally, when TSAT changes between 30% and 40%, there is no apparent improvement in Hb response. Hemoglobin response to ESA appeared to decrease at TSAT levels above 40%, but caution should be used when interpreting this result because of data sparseness at higher TSAT values.


TSAT is a better predictor than ferritin of hemoglobin response to Epoetin alfa in US dialysis patients.

Gaweda AE, Bhat P, Maglinte GA, Chang CL, Hill J, Park GS, Ashfaq A, Gitlin M - Hemodial Int (2013)

Relative hemoglobin (Hb) response from interval k to k‚ÄČ+‚ÄČ1 to a fixed-unit Epoetin alfa dose change from interval k‚ÄČ‚ąí‚ÄČ1 to k across transferrin saturation (TSAT) values, derived from the TSAT model. ESA‚ÄČ=‚ÄČerythropoiesis-stimulating agent.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232318&req=5

fig03: Relative hemoglobin (Hb) response from interval k to k‚ÄČ+‚ÄČ1 to a fixed-unit Epoetin alfa dose change from interval k‚ÄČ‚ąí‚ÄČ1 to k across transferrin saturation (TSAT) values, derived from the TSAT model. ESA‚ÄČ=‚ÄČerythropoiesis-stimulating agent.
Mentions: Figure‚ÄČ3 depicts the change in Hb response as a function of TSAT (Equation (1)). Maximum Hb response to ESA was reached at TSAT of 35%. As indicated by the increasing slope of the curve, increasing TSAT from 0% to 10% leads to a strong improvement in Hb response. Each subsequent increase in TSAT, from 10% to 20% and again from 20% to 30%, results in diminished improvement in Hb response by approximately one-half. Finally, when TSAT changes between 30% and 40%, there is no apparent improvement in Hb response. Hemoglobin response to ESA appeared to decrease at TSAT levels above 40%, but caution should be used when interpreting this result because of data sparseness at higher TSAT values.

Bottom Line: Transferrin saturation, but not ferritin, had a statistically significant (P < 0.05) modifying effect on Hb response.Maximum Hb response was achieved when TSAT was 34%, with minimal incremental effect beyond these levels.Long-term safety of iron use to improve Hb response to ESA warrants further study.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Medicine, University of Louisville, Louisville, Kentucky, USA.

Show MeSH
Related in: MedlinePlus