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Nutritional programming of coenzyme Q: potential for prevention and intervention?

Tarry-Adkins JL, Fernandez-Twinn DS, Chen JH, Hargreaves IP, Martin-Gronert MS, McConnell JM, Ozanne SE - FASEB J. (2014)

Bottom Line: Postweaning dietary supplementation with CoQ prevented these detrimental programming effects.Recuperated WBCs also had reduced CoQ (74±5.8%; P<0.05).We conclude that early intervention with CoQ in at-risk individuals may be a cost-effective and safe way of reducing the global burden of CVDs.

View Article: PubMed Central - PubMed

Affiliation: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; and janeadkins@googlemail.com.

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Effect of in utero protein restriction and accelerated postnatal growth on antioxidant protein expression in 22 d (A) and 12 mo (B, C) male rat aortas. C, control; CQ, control CoQ; R, recuperated; RQ, recuperated CoQ. Results are expressed as means ± sem. *P < 0.05, ***P < 0.001; n = 6/group.
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Figure 5: Effect of in utero protein restriction and accelerated postnatal growth on antioxidant protein expression in 22 d (A) and 12 mo (B, C) male rat aortas. C, control; CQ, control CoQ; R, recuperated; RQ, recuperated CoQ. Results are expressed as means ± sem. *P < 0.05, ***P < 0.001; n = 6/group.

Mentions: At 22 d of age, MnSOD and catalase protein levels were significantly (P<0.001) increased in the recuperated group compared with controls (Fig. 5A). At 12 mo of age, MnSOD levels were significantly reduced in the recuperated group; however, this decrease was not ameliorated by CoQ10 supplementation (Fig. 5B). Catalase levels (P<0.05) remained significantly elevated in the recuperated group compared with controls at 12 mo of age. However, CoQ10 supplementation significantly (P<0.001) decreased catalase protein expression (Fig. 5C).


Nutritional programming of coenzyme Q: potential for prevention and intervention?

Tarry-Adkins JL, Fernandez-Twinn DS, Chen JH, Hargreaves IP, Martin-Gronert MS, McConnell JM, Ozanne SE - FASEB J. (2014)

Effect of in utero protein restriction and accelerated postnatal growth on antioxidant protein expression in 22 d (A) and 12 mo (B, C) male rat aortas. C, control; CQ, control CoQ; R, recuperated; RQ, recuperated CoQ. Results are expressed as means ± sem. *P < 0.05, ***P < 0.001; n = 6/group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232289&req=5

Figure 5: Effect of in utero protein restriction and accelerated postnatal growth on antioxidant protein expression in 22 d (A) and 12 mo (B, C) male rat aortas. C, control; CQ, control CoQ; R, recuperated; RQ, recuperated CoQ. Results are expressed as means ± sem. *P < 0.05, ***P < 0.001; n = 6/group.
Mentions: At 22 d of age, MnSOD and catalase protein levels were significantly (P<0.001) increased in the recuperated group compared with controls (Fig. 5A). At 12 mo of age, MnSOD levels were significantly reduced in the recuperated group; however, this decrease was not ameliorated by CoQ10 supplementation (Fig. 5B). Catalase levels (P<0.05) remained significantly elevated in the recuperated group compared with controls at 12 mo of age. However, CoQ10 supplementation significantly (P<0.001) decreased catalase protein expression (Fig. 5C).

Bottom Line: Postweaning dietary supplementation with CoQ prevented these detrimental programming effects.Recuperated WBCs also had reduced CoQ (74±5.8%; P<0.05).We conclude that early intervention with CoQ in at-risk individuals may be a cost-effective and safe way of reducing the global burden of CVDs.

View Article: PubMed Central - PubMed

Affiliation: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; and janeadkins@googlemail.com.

Show MeSH
Related in: MedlinePlus