Nutritional programming of coenzyme Q: potential for prevention and intervention?
Bottom Line: Postweaning dietary supplementation with CoQ prevented these detrimental programming effects.Recuperated WBCs also had reduced CoQ (74±5.8%; P<0.05).We conclude that early intervention with CoQ in at-risk individuals may be a cost-effective and safe way of reducing the global burden of CVDs.
Affiliation: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; and email@example.com.Show MeSH
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Mentions: At 22 d of age, MnSOD and catalase protein levels were significantly (P<0.001) increased in the recuperated group compared with controls (Fig. 5A). At 12 mo of age, MnSOD levels were significantly reduced in the recuperated group; however, this decrease was not ameliorated by CoQ10 supplementation (Fig. 5B). Catalase levels (P<0.05) remained significantly elevated in the recuperated group compared with controls at 12 mo of age. However, CoQ10 supplementation significantly (P<0.001) decreased catalase protein expression (Fig. 5C).
Affiliation: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; and firstname.lastname@example.org.