Nutritional programming of coenzyme Q: potential for prevention and intervention?
Bottom Line: Postweaning dietary supplementation with CoQ prevented these detrimental programming effects.Recuperated WBCs also had reduced CoQ (74±5.8%; P<0.05).We conclude that early intervention with CoQ in at-risk individuals may be a cost-effective and safe way of reducing the global burden of CVDs.
Affiliation: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; and firstname.lastname@example.org.Show MeSH
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Mentions: At 22 d of age, aortic CoQ9 concentration was significantly reduced (P<0.05) in the recuperated group compared with controls (Fig. 2A). There was also an effect of aging such that CoQ9 levels in 12 mo aortas were significantly (P<0.05) lower than those observed at 22 d of age. At 12 mo of age, both aortic and WBC levels of CoQ9 were significantly reduced (P<0.05) in the recuperated group compared with control animals (Fig. 2A). CoQ10 supplementation had no effect on aortic CoQ9 levels in control animals (203±39 vs. 196±35 pmol/mg protein) nor in recuperated animals (119±15 vs. 158±30 pmol/mg protein). Likewise, CoQ9 levels in WBCs were also unaffected by CoQ10 supplementation (control: 161±32; control CoQ: 140±17; recuperated: 111±4; recuperated CoQ: 108±12 pmol/mg protein). Interestingly however, a strong positive correlation (P<0.0001; r2=0.84) was observed between aortic and WBC CoQ9 concentrations at 12 mo of age in control and recuperated offspring (Fig. 2B).
Affiliation: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; and email@example.com.