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Nutritional programming of coenzyme Q: potential for prevention and intervention?

Tarry-Adkins JL, Fernandez-Twinn DS, Chen JH, Hargreaves IP, Martin-Gronert MS, McConnell JM, Ozanne SE - FASEB J. (2014)

Bottom Line: Postweaning dietary supplementation with CoQ prevented these detrimental programming effects.Recuperated WBCs also had reduced CoQ (74±5.8%; P<0.05).We conclude that early intervention with CoQ in at-risk individuals may be a cost-effective and safe way of reducing the global burden of CVDs.

View Article: PubMed Central - PubMed

Affiliation: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; and janeadkins@googlemail.com.

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Effect of in utero protein restriction and accelerated postnatal growth on preweaning body weights. Results are expressed as means ± sem. ***P < 0.001 for recuperated (R) vs. control (C); n=10/group.
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Figure 1: Effect of in utero protein restriction and accelerated postnatal growth on preweaning body weights. Results are expressed as means ± sem. ***P < 0.001 for recuperated (R) vs. control (C); n=10/group.

Mentions: At postnatal d 3 and 7, recuperated pups were significantly (P<0.001) lighter compared with control offspring. However, by postnatal d 21, this group had undergone accelerated postnatal growth; therefore, the body weights were similar between groups (Fig. 1). At 12 mo of age, body weight remained similar between groups (Table 1).


Nutritional programming of coenzyme Q: potential for prevention and intervention?

Tarry-Adkins JL, Fernandez-Twinn DS, Chen JH, Hargreaves IP, Martin-Gronert MS, McConnell JM, Ozanne SE - FASEB J. (2014)

Effect of in utero protein restriction and accelerated postnatal growth on preweaning body weights. Results are expressed as means ± sem. ***P < 0.001 for recuperated (R) vs. control (C); n=10/group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232289&req=5

Figure 1: Effect of in utero protein restriction and accelerated postnatal growth on preweaning body weights. Results are expressed as means ± sem. ***P < 0.001 for recuperated (R) vs. control (C); n=10/group.
Mentions: At postnatal d 3 and 7, recuperated pups were significantly (P<0.001) lighter compared with control offspring. However, by postnatal d 21, this group had undergone accelerated postnatal growth; therefore, the body weights were similar between groups (Fig. 1). At 12 mo of age, body weight remained similar between groups (Table 1).

Bottom Line: Postweaning dietary supplementation with CoQ prevented these detrimental programming effects.Recuperated WBCs also had reduced CoQ (74±5.8%; P<0.05).We conclude that early intervention with CoQ in at-risk individuals may be a cost-effective and safe way of reducing the global burden of CVDs.

View Article: PubMed Central - PubMed

Affiliation: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; and janeadkins@googlemail.com.

Show MeSH
Related in: MedlinePlus