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Improved pharmacokinetics of sumatriptan with Breath Powered™ nasal delivery of sumatriptan powder.

Obaidi M, Offman E, Messina J, Carothers J, Djupesland PG, Mahmoud RA - Headache (2013)

Bottom Line: A prior PK study found that low doses of sumatriptan powder delivered intranasally with a Breath Powered device were efficiently and rapidly absorbed.Quantitative measurement of residuals in used Breath Powered devices demonstrated that the devices delivered 8±0.9 mg (mean±standard deviation) of sumatriptan powder in each nostril (total dose 16 mg).The magnitude of difference is larger on a per-milligram basis.

View Article: PubMed Central - PubMed

Affiliation: Lincoln, NE, USA.

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Related in: MedlinePlus

Gamma camera images 2 minutes after delivery using a traditional liquid spray (a) and powder with OptiNose Breath Powered device (b) shown with a logarithmic hot iron intensity scale (reference). Deposition of spray was greatest anterior to the nasal valve and in the lower posterior region of the nose (“floor” of the nasal cavity), whereas deposition of powder was shifted to more superior posterior regions of the nose. The images were from the same subject after each method of administration.
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fig01: Gamma camera images 2 minutes after delivery using a traditional liquid spray (a) and powder with OptiNose Breath Powered device (b) shown with a logarithmic hot iron intensity scale (reference). Deposition of spray was greatest anterior to the nasal valve and in the lower posterior region of the nose (“floor” of the nasal cavity), whereas deposition of powder was shifted to more superior posterior regions of the nose. The images were from the same subject after each method of administration.

Mentions: Human in vivo deposition studies using Breath Powered delivery of radio-labeled lactose powder have demonstrated a superior pattern of delivery to the deep nasal regions beyond the nasal valve compared with radio-labeled liquid delivered with a conventional nasal spray pump (Fig. 1), with protection from lung deposition.11,16


Improved pharmacokinetics of sumatriptan with Breath Powered™ nasal delivery of sumatriptan powder.

Obaidi M, Offman E, Messina J, Carothers J, Djupesland PG, Mahmoud RA - Headache (2013)

Gamma camera images 2 minutes after delivery using a traditional liquid spray (a) and powder with OptiNose Breath Powered device (b) shown with a logarithmic hot iron intensity scale (reference). Deposition of spray was greatest anterior to the nasal valve and in the lower posterior region of the nose (“floor” of the nasal cavity), whereas deposition of powder was shifted to more superior posterior regions of the nose. The images were from the same subject after each method of administration.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232272&req=5

fig01: Gamma camera images 2 minutes after delivery using a traditional liquid spray (a) and powder with OptiNose Breath Powered device (b) shown with a logarithmic hot iron intensity scale (reference). Deposition of spray was greatest anterior to the nasal valve and in the lower posterior region of the nose (“floor” of the nasal cavity), whereas deposition of powder was shifted to more superior posterior regions of the nose. The images were from the same subject after each method of administration.
Mentions: Human in vivo deposition studies using Breath Powered delivery of radio-labeled lactose powder have demonstrated a superior pattern of delivery to the deep nasal regions beyond the nasal valve compared with radio-labeled liquid delivered with a conventional nasal spray pump (Fig. 1), with protection from lung deposition.11,16

Bottom Line: A prior PK study found that low doses of sumatriptan powder delivered intranasally with a Breath Powered device were efficiently and rapidly absorbed.Quantitative measurement of residuals in used Breath Powered devices demonstrated that the devices delivered 8±0.9 mg (mean±standard deviation) of sumatriptan powder in each nostril (total dose 16 mg).The magnitude of difference is larger on a per-milligram basis.

View Article: PubMed Central - PubMed

Affiliation: Lincoln, NE, USA.

Show MeSH
Related in: MedlinePlus