Improved pharmacokinetics of sumatriptan with Breath Powered™ nasal delivery of sumatriptan powder.
Bottom Line: A prior PK study found that low doses of sumatriptan powder delivered intranasally with a Breath Powered device were efficiently and rapidly absorbed.Quantitative measurement of residuals in used Breath Powered devices demonstrated that the devices delivered 8±0.9 mg (mean±standard deviation) of sumatriptan powder in each nostril (total dose 16 mg).The magnitude of difference is larger on a per-milligram basis.
Affiliation: Lincoln, NE, USA.Show MeSH
Related in: MedlinePlus
Mentions: Human in vivo deposition studies using Breath Powered delivery of radio-labeled lactose powder have demonstrated a superior pattern of delivery to the deep nasal regions beyond the nasal valve compared with radio-labeled liquid delivered with a conventional nasal spray pump (Fig. 1), with protection from lung deposition.11,16