The burden of invasive pneumococcal disease in children with underlying risk factors in North America and Europe.
Bottom Line: Characterisation of risk groups who may benefit from pneumococcal vaccination is essential for the generation of recommendations and policy.Studies investigating changes in incidence over time reported decreases in the incidence of IPD between the late 1990s and early 2000s.There was, however, a clear decrease in the incidence of IPD in at-risk children after the introduction of 7-valent pneumococcal conjugate vaccine into immunisation programmes, as previously demonstrated in the general population.
Affiliation: Children's Hospital, Goethe University, Frankfurt, Germany.Show MeSH
Related in: MedlinePlus
Mentions: In total, 1640 references were identified by the literature search, of which 1435 were excluded on the basis of the title or abstract; the remaining 18 references met the inclusion and exclusion criteria (Figure1) 22–39. A further 10 papers were identified that reported incidence of IPD in indigenous populations and specific ethnic populations considered to be at increased risk of IPD 40–49. While these socioeconomic risk groups are outside the scope of this review, the details of these papers are presented in supplementary tables for the reader's interest (Tables S1 and S2).
Affiliation: Children's Hospital, Goethe University, Frankfurt, Germany.