Limits...
Stem memory T cells (TSCM)-their role in cancer and HIV immunotherapies.

Flynn JK, Gorry PR - Clin Transl Immunology (2014)

Bottom Line: Stem memory T cells (TSCM) have been described in mice, non-human primates and in humans, constituting approximately 2-4% of the total CD4(+) and CD8(+) T-cell population in the periphery.TSCM represent the earliest and long-lasting developmental stage of memory T cells, displaying stem cell-like properties, and exhibiting a gene profile between naïve and central memory T cells.How and when the formation of TSCM occurs during the immune response to pathogens and the therapeutic potential of these cells are currently being investigated.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Research, Burnet Institute , Melbourne, Victoria, Australia ; Department of Infectious Diseases, Monash University , Melbourne, Victoria, Australia.

ABSTRACT
Stem memory T cells (TSCM) have been described in mice, non-human primates and in humans, constituting approximately 2-4% of the total CD4(+) and CD8(+) T-cell population in the periphery. TSCM represent the earliest and long-lasting developmental stage of memory T cells, displaying stem cell-like properties, and exhibiting a gene profile between naïve and central memory T cells. Their self-renewal capacity and long-term survival has sparked interest in the cancer and human immunodeficiency virus (HIV) fields. How and when the formation of TSCM occurs during the immune response to pathogens and the therapeutic potential of these cells are currently being investigated. This review will explore the potential role of TSCM to be used as, or targeted by, immunotherapies and vaccines for treatment of cancer and HIV.

No MeSH data available.


Related in: MedlinePlus

Following the theory of a linear hierarchical system, upon antigen exposure, naïve T cells proliferate and differentiate into memory T cells. Transition into more differentiated memory T-cell subsets has been described as progressively acquiring the capacity to respond to cytokines, tissue homing receptors, antiapoptotic molecules and acquiring effector functions, whilst also losing the expression of lymph node homing receptors, the capacity for proliferation, IL-2 production, self-renewal and survival. APC, antigen-presenting cell.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4232066&req=5

fig3: Following the theory of a linear hierarchical system, upon antigen exposure, naïve T cells proliferate and differentiate into memory T cells. Transition into more differentiated memory T-cell subsets has been described as progressively acquiring the capacity to respond to cytokines, tissue homing receptors, antiapoptotic molecules and acquiring effector functions, whilst also losing the expression of lymph node homing receptors, the capacity for proliferation, IL-2 production, self-renewal and survival. APC, antigen-presenting cell.

Mentions: More recently, the notion that CM T cells demonstrate stem cell-like characteristics with their capacity to self-renew and also to generate more differentiated progeny from antigen stimulation14 has been challenged by the discovery of an earlier stage memory T cell15, 16 (Figure 3). This novel T-cell subset, termed stem memory T cells (TSCM) has been detected in CD4+ and CD8+ T-cell populations of mice,17 non-human primates (NHP)16, 18 and humans.15, 17 TSCM display stem cell-like properties and constitute a small proportion of the memory T-cell subset, approximately 2–4% of the total CD4+ and CD8+ T-cell population in the blood.15, 18 TSCM have been described as representing the earliest and longest lasting developmental stage of memory T cells15 and exhibiting a gene profile which is between naïve and CM T cells.15, 18


Stem memory T cells (TSCM)-their role in cancer and HIV immunotherapies.

Flynn JK, Gorry PR - Clin Transl Immunology (2014)

Following the theory of a linear hierarchical system, upon antigen exposure, naïve T cells proliferate and differentiate into memory T cells. Transition into more differentiated memory T-cell subsets has been described as progressively acquiring the capacity to respond to cytokines, tissue homing receptors, antiapoptotic molecules and acquiring effector functions, whilst also losing the expression of lymph node homing receptors, the capacity for proliferation, IL-2 production, self-renewal and survival. APC, antigen-presenting cell.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232066&req=5

fig3: Following the theory of a linear hierarchical system, upon antigen exposure, naïve T cells proliferate and differentiate into memory T cells. Transition into more differentiated memory T-cell subsets has been described as progressively acquiring the capacity to respond to cytokines, tissue homing receptors, antiapoptotic molecules and acquiring effector functions, whilst also losing the expression of lymph node homing receptors, the capacity for proliferation, IL-2 production, self-renewal and survival. APC, antigen-presenting cell.
Mentions: More recently, the notion that CM T cells demonstrate stem cell-like characteristics with their capacity to self-renew and also to generate more differentiated progeny from antigen stimulation14 has been challenged by the discovery of an earlier stage memory T cell15, 16 (Figure 3). This novel T-cell subset, termed stem memory T cells (TSCM) has been detected in CD4+ and CD8+ T-cell populations of mice,17 non-human primates (NHP)16, 18 and humans.15, 17 TSCM display stem cell-like properties and constitute a small proportion of the memory T-cell subset, approximately 2–4% of the total CD4+ and CD8+ T-cell population in the blood.15, 18 TSCM have been described as representing the earliest and longest lasting developmental stage of memory T cells15 and exhibiting a gene profile which is between naïve and CM T cells.15, 18

Bottom Line: Stem memory T cells (TSCM) have been described in mice, non-human primates and in humans, constituting approximately 2-4% of the total CD4(+) and CD8(+) T-cell population in the periphery.TSCM represent the earliest and long-lasting developmental stage of memory T cells, displaying stem cell-like properties, and exhibiting a gene profile between naïve and central memory T cells.How and when the formation of TSCM occurs during the immune response to pathogens and the therapeutic potential of these cells are currently being investigated.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Research, Burnet Institute , Melbourne, Victoria, Australia ; Department of Infectious Diseases, Monash University , Melbourne, Victoria, Australia.

ABSTRACT
Stem memory T cells (TSCM) have been described in mice, non-human primates and in humans, constituting approximately 2-4% of the total CD4(+) and CD8(+) T-cell population in the periphery. TSCM represent the earliest and long-lasting developmental stage of memory T cells, displaying stem cell-like properties, and exhibiting a gene profile between naïve and central memory T cells. Their self-renewal capacity and long-term survival has sparked interest in the cancer and human immunodeficiency virus (HIV) fields. How and when the formation of TSCM occurs during the immune response to pathogens and the therapeutic potential of these cells are currently being investigated. This review will explore the potential role of TSCM to be used as, or targeted by, immunotherapies and vaccines for treatment of cancer and HIV.

No MeSH data available.


Related in: MedlinePlus