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Stem memory T cells (TSCM)-their role in cancer and HIV immunotherapies.

Flynn JK, Gorry PR - Clin Transl Immunology (2014)

Bottom Line: Stem memory T cells (TSCM) have been described in mice, non-human primates and in humans, constituting approximately 2-4% of the total CD4(+) and CD8(+) T-cell population in the periphery.TSCM represent the earliest and long-lasting developmental stage of memory T cells, displaying stem cell-like properties, and exhibiting a gene profile between naïve and central memory T cells.How and when the formation of TSCM occurs during the immune response to pathogens and the therapeutic potential of these cells are currently being investigated.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Research, Burnet Institute , Melbourne, Victoria, Australia ; Department of Infectious Diseases, Monash University , Melbourne, Victoria, Australia.

ABSTRACT
Stem memory T cells (TSCM) have been described in mice, non-human primates and in humans, constituting approximately 2-4% of the total CD4(+) and CD8(+) T-cell population in the periphery. TSCM represent the earliest and long-lasting developmental stage of memory T cells, displaying stem cell-like properties, and exhibiting a gene profile between naïve and central memory T cells. Their self-renewal capacity and long-term survival has sparked interest in the cancer and human immunodeficiency virus (HIV) fields. How and when the formation of TSCM occurs during the immune response to pathogens and the therapeutic potential of these cells are currently being investigated. This review will explore the potential role of TSCM to be used as, or targeted by, immunotherapies and vaccines for treatment of cancer and HIV.

No MeSH data available.


Related in: MedlinePlus

Following antigen exposure, naïve T cells undergo proliferative expansion and differentiate into memory T-cell subsets, which culminate into terminally differentiated effector T cells. A majority of memory T cells will survive the contraction phase and become long-lived memory T cells, which have the ability to acquire effector functions upon antigen re-exposure. APC, antigen-presenting cell.
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fig1: Following antigen exposure, naïve T cells undergo proliferative expansion and differentiate into memory T-cell subsets, which culminate into terminally differentiated effector T cells. A majority of memory T cells will survive the contraction phase and become long-lived memory T cells, which have the ability to acquire effector functions upon antigen re-exposure. APC, antigen-presenting cell.

Mentions: Memory T cells have an important role in the adaptive immune response to infectious diseases and cancer.1, 2, 3, 4, 5 Following exposure to antigen, naïve T cells undergo proliferative expansion and differentiation into memory T-cell subsets, culminating into terminally differentiated effector T cells.6, 7 As T cells mature, they progressively acquire effector functions and lose the ability for self-renewal and survival.4 A minority will survive the contraction phase and become long-lived memory T cells, which have the ability to acquire effector functions upon reinfection5, 6 (Figure 1).


Stem memory T cells (TSCM)-their role in cancer and HIV immunotherapies.

Flynn JK, Gorry PR - Clin Transl Immunology (2014)

Following antigen exposure, naïve T cells undergo proliferative expansion and differentiate into memory T-cell subsets, which culminate into terminally differentiated effector T cells. A majority of memory T cells will survive the contraction phase and become long-lived memory T cells, which have the ability to acquire effector functions upon antigen re-exposure. APC, antigen-presenting cell.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232066&req=5

fig1: Following antigen exposure, naïve T cells undergo proliferative expansion and differentiate into memory T-cell subsets, which culminate into terminally differentiated effector T cells. A majority of memory T cells will survive the contraction phase and become long-lived memory T cells, which have the ability to acquire effector functions upon antigen re-exposure. APC, antigen-presenting cell.
Mentions: Memory T cells have an important role in the adaptive immune response to infectious diseases and cancer.1, 2, 3, 4, 5 Following exposure to antigen, naïve T cells undergo proliferative expansion and differentiation into memory T-cell subsets, culminating into terminally differentiated effector T cells.6, 7 As T cells mature, they progressively acquire effector functions and lose the ability for self-renewal and survival.4 A minority will survive the contraction phase and become long-lived memory T cells, which have the ability to acquire effector functions upon reinfection5, 6 (Figure 1).

Bottom Line: Stem memory T cells (TSCM) have been described in mice, non-human primates and in humans, constituting approximately 2-4% of the total CD4(+) and CD8(+) T-cell population in the periphery.TSCM represent the earliest and long-lasting developmental stage of memory T cells, displaying stem cell-like properties, and exhibiting a gene profile between naïve and central memory T cells.How and when the formation of TSCM occurs during the immune response to pathogens and the therapeutic potential of these cells are currently being investigated.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Research, Burnet Institute , Melbourne, Victoria, Australia ; Department of Infectious Diseases, Monash University , Melbourne, Victoria, Australia.

ABSTRACT
Stem memory T cells (TSCM) have been described in mice, non-human primates and in humans, constituting approximately 2-4% of the total CD4(+) and CD8(+) T-cell population in the periphery. TSCM represent the earliest and long-lasting developmental stage of memory T cells, displaying stem cell-like properties, and exhibiting a gene profile between naïve and central memory T cells. Their self-renewal capacity and long-term survival has sparked interest in the cancer and human immunodeficiency virus (HIV) fields. How and when the formation of TSCM occurs during the immune response to pathogens and the therapeutic potential of these cells are currently being investigated. This review will explore the potential role of TSCM to be used as, or targeted by, immunotherapies and vaccines for treatment of cancer and HIV.

No MeSH data available.


Related in: MedlinePlus