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A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes.

McGeoch SC, Johnstone AM, Lobley GE, Adamson J, Hickson K, Holtrop G, Fyfe C, Clark LF, Pearson DW, Abraham P, Megson IL, MacRury SM - Diabet. Med. (2013)

Bottom Line: Markers of inflammation and oxidative stress, including high-sensitivity C-reactive protein, interleukin 6, interleukin 18, tumour necrosis factor-alpha, adiponectin, thiobarbituric acid reactive substances, oxygen radical antioxidant capacity, oxidized LDL and urinary isoprostanes, were also measured at fasting and in the postprandial period.There were no diet-related effects on glycaemic control or glycaemic or insulinaemic responses to the test meal.There was a postprandial decline in adiponectin concentration (P = 0.009), but no effect of dietary intervention.

View Article: PubMed Central - PubMed

Affiliation: The Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK; Department of Diabetes, Aberdeen Royal Infirmary, Aberdeen, UK.

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Adiponectin concentrations following the standard test meal at baseline and following dietary intervention. Values are means. Habitual (pre-intervention) (); standard dietary advice (); oat-enriched diet (). Effect of time, P = 0.009. Effect of diet, P = 0.452. Interaction between postprandial time × diet, P = 0.582.
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fig03: Adiponectin concentrations following the standard test meal at baseline and following dietary intervention. Values are means. Habitual (pre-intervention) (); standard dietary advice (); oat-enriched diet (). Effect of time, P = 0.009. Effect of diet, P = 0.452. Interaction between postprandial time × diet, P = 0.582.

Mentions: For nine volunteers, IL-18 concentrations were below the limit of assay detection (9 pg/ml), but for those subjects with detectable IL-18 at baseline (n = 18), both fasted and postprandial values were higher (P = 0.001) following standard dietary advice than either the habitual or oat-enriched diet. There was no effect of diet on fasting or postprandial concentrations of other markers of inflammation or oxidative stress (Table6). However, there was a postprandial decline (P = 0.009) in adiponectin concentrations following the standard test meal. This was not affected by chronic diet (Fig.3).


A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes.

McGeoch SC, Johnstone AM, Lobley GE, Adamson J, Hickson K, Holtrop G, Fyfe C, Clark LF, Pearson DW, Abraham P, Megson IL, MacRury SM - Diabet. Med. (2013)

Adiponectin concentrations following the standard test meal at baseline and following dietary intervention. Values are means. Habitual (pre-intervention) (); standard dietary advice (); oat-enriched diet (). Effect of time, P = 0.009. Effect of diet, P = 0.452. Interaction between postprandial time × diet, P = 0.582.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232050&req=5

fig03: Adiponectin concentrations following the standard test meal at baseline and following dietary intervention. Values are means. Habitual (pre-intervention) (); standard dietary advice (); oat-enriched diet (). Effect of time, P = 0.009. Effect of diet, P = 0.452. Interaction between postprandial time × diet, P = 0.582.
Mentions: For nine volunteers, IL-18 concentrations were below the limit of assay detection (9 pg/ml), but for those subjects with detectable IL-18 at baseline (n = 18), both fasted and postprandial values were higher (P = 0.001) following standard dietary advice than either the habitual or oat-enriched diet. There was no effect of diet on fasting or postprandial concentrations of other markers of inflammation or oxidative stress (Table6). However, there was a postprandial decline (P = 0.009) in adiponectin concentrations following the standard test meal. This was not affected by chronic diet (Fig.3).

Bottom Line: Markers of inflammation and oxidative stress, including high-sensitivity C-reactive protein, interleukin 6, interleukin 18, tumour necrosis factor-alpha, adiponectin, thiobarbituric acid reactive substances, oxygen radical antioxidant capacity, oxidized LDL and urinary isoprostanes, were also measured at fasting and in the postprandial period.There were no diet-related effects on glycaemic control or glycaemic or insulinaemic responses to the test meal.There was a postprandial decline in adiponectin concentration (P = 0.009), but no effect of dietary intervention.

View Article: PubMed Central - PubMed

Affiliation: The Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK; Department of Diabetes, Aberdeen Royal Infirmary, Aberdeen, UK.

Show MeSH
Related in: MedlinePlus