Spinal ephrinB/EphB signalling contributed to remifentanil-induced hyperalgesia via NMDA receptor.
Bottom Line: Continuing infusion of remifentanil produced a thermal hyperalgesia and mechanical allodynia, which was accompanied with increased protein expression of spinal-level EphB1 receptor, ephrinB1 ligand and Fos; what appeared above was suppressed by pretreatment with EphB1-Fc, an antagonist of ephrinB/EphB or MK-801, and increased pain behaviours induced by intrathecal injection of ephrinB1-Fc, an agonist of ephrinB/EphB, were suppressed by MK-801.Our findings indicated that ephrinB/EphB signalling is involved in RIH.EphrinB/EphB signalling might be the upstream of NMDA receptor.
Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.Show MeSH
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Mentions: We examined the effect of remifentanil treatment on spinal-level Fos protein expression. In the RIH group, it was increased by approximately 35% ± 2% and 27% ± 1.5% 1 and 3 days after surgery, respectively, compared with group CON (p < 0.01, group RIH compared with group CON, n = 6 per group; Fig. 3A–D).
Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.