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Spinal ephrinB/EphB signalling contributed to remifentanil-induced hyperalgesia via NMDA receptor.

Xia WS, Peng YN, Tang LH, Jiang LS, Yu LN, Zhou XL, Zhang FJ, Yan M - Eur J Pain (2014)

Bottom Line: Continuing infusion of remifentanil produced a thermal hyperalgesia and mechanical allodynia, which was accompanied with increased protein expression of spinal-level EphB1 receptor, ephrinB1 ligand and Fos; what appeared above was suppressed by pretreatment with EphB1-Fc, an antagonist of ephrinB/EphB or MK-801, and increased pain behaviours induced by intrathecal injection of ephrinB1-Fc, an agonist of ephrinB/EphB, were suppressed by MK-801.Our findings indicated that ephrinB/EphB signalling is involved in RIH.EphrinB/EphB signalling might be the upstream of NMDA receptor.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

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Related in: MedlinePlus

The expression of Fos in the spinal cord dorsal horn of the rats in each group at first (A and B) and third day (C and D) after surgery. Scale bar represented 100 μm. Data were shown as the mean ± standard deviation. **p < 0.01, compared with group CON; ##p < 0.01, compared with group remifentanil-induced hyperalgesia (RIH); n = 6 rats in each group.
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fig03: The expression of Fos in the spinal cord dorsal horn of the rats in each group at first (A and B) and third day (C and D) after surgery. Scale bar represented 100 μm. Data were shown as the mean ± standard deviation. **p < 0.01, compared with group CON; ##p < 0.01, compared with group remifentanil-induced hyperalgesia (RIH); n = 6 rats in each group.

Mentions: We examined the effect of remifentanil treatment on spinal-level Fos protein expression. In the RIH group, it was increased by approximately 35% ± 2% and 27% ± 1.5% 1 and 3 days after surgery, respectively, compared with group CON (p < 0.01, group RIH compared with group CON, n = 6 per group; Fig. 3A–D).


Spinal ephrinB/EphB signalling contributed to remifentanil-induced hyperalgesia via NMDA receptor.

Xia WS, Peng YN, Tang LH, Jiang LS, Yu LN, Zhou XL, Zhang FJ, Yan M - Eur J Pain (2014)

The expression of Fos in the spinal cord dorsal horn of the rats in each group at first (A and B) and third day (C and D) after surgery. Scale bar represented 100 μm. Data were shown as the mean ± standard deviation. **p < 0.01, compared with group CON; ##p < 0.01, compared with group remifentanil-induced hyperalgesia (RIH); n = 6 rats in each group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232047&req=5

fig03: The expression of Fos in the spinal cord dorsal horn of the rats in each group at first (A and B) and third day (C and D) after surgery. Scale bar represented 100 μm. Data were shown as the mean ± standard deviation. **p < 0.01, compared with group CON; ##p < 0.01, compared with group remifentanil-induced hyperalgesia (RIH); n = 6 rats in each group.
Mentions: We examined the effect of remifentanil treatment on spinal-level Fos protein expression. In the RIH group, it was increased by approximately 35% ± 2% and 27% ± 1.5% 1 and 3 days after surgery, respectively, compared with group CON (p < 0.01, group RIH compared with group CON, n = 6 per group; Fig. 3A–D).

Bottom Line: Continuing infusion of remifentanil produced a thermal hyperalgesia and mechanical allodynia, which was accompanied with increased protein expression of spinal-level EphB1 receptor, ephrinB1 ligand and Fos; what appeared above was suppressed by pretreatment with EphB1-Fc, an antagonist of ephrinB/EphB or MK-801, and increased pain behaviours induced by intrathecal injection of ephrinB1-Fc, an agonist of ephrinB/EphB, were suppressed by MK-801.Our findings indicated that ephrinB/EphB signalling is involved in RIH.EphrinB/EphB signalling might be the upstream of NMDA receptor.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Show MeSH
Related in: MedlinePlus