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Spinal ephrinB/EphB signalling contributed to remifentanil-induced hyperalgesia via NMDA receptor.

Xia WS, Peng YN, Tang LH, Jiang LS, Yu LN, Zhou XL, Zhang FJ, Yan M - Eur J Pain (2014)

Bottom Line: Continuing infusion of remifentanil produced a thermal hyperalgesia and mechanical allodynia, which was accompanied with increased protein expression of spinal-level EphB1 receptor, ephrinB1 ligand and Fos; what appeared above was suppressed by pretreatment with EphB1-Fc, an antagonist of ephrinB/EphB or MK-801, and increased pain behaviours induced by intrathecal injection of ephrinB1-Fc, an agonist of ephrinB/EphB, were suppressed by MK-801.Our findings indicated that ephrinB/EphB signalling is involved in RIH.EphrinB/EphB signalling might be the upstream of NMDA receptor.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

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The effects of EphB1-Fc and MK-801 on mechanical allodynia (A) and thermal hyperalgesia (B) induced by remifentanil in rats. Data were shown as the mean ± standard deviation. **p < 0.01, compared with group CON; #p < 0.05, ##p < 0.01, compared with group remifentanil-induced hyperalgesia (RIH); n = 6 rats in each group. PWL, paw withdrawal latency; PWT, paw withdrawal threshold.
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fig01: The effects of EphB1-Fc and MK-801 on mechanical allodynia (A) and thermal hyperalgesia (B) induced by remifentanil in rats. Data were shown as the mean ± standard deviation. **p < 0.01, compared with group CON; #p < 0.05, ##p < 0.01, compared with group remifentanil-induced hyperalgesia (RIH); n = 6 rats in each group. PWL, paw withdrawal latency; PWT, paw withdrawal threshold.

Mentions: At 2 h after plantar incision, a significant decrease in both mechanical and thermal nociceptive thresholds was observed (4.06 ± 0.95 g and 8.38 ± 1.50 s) compared with control group (7.83 ± 0.98 g and 11.34 ± 2.02 s). On day 1 after manipulation, remifentanil induced a significant decrease in both mechanical and thermal hypersensitivity (about 55% ± 3% and 41% ± 2%, respectively) (p < 0.01, group RIH compared with group CON, n = 6 per group; Fig. 1A and B).


Spinal ephrinB/EphB signalling contributed to remifentanil-induced hyperalgesia via NMDA receptor.

Xia WS, Peng YN, Tang LH, Jiang LS, Yu LN, Zhou XL, Zhang FJ, Yan M - Eur J Pain (2014)

The effects of EphB1-Fc and MK-801 on mechanical allodynia (A) and thermal hyperalgesia (B) induced by remifentanil in rats. Data were shown as the mean ± standard deviation. **p < 0.01, compared with group CON; #p < 0.05, ##p < 0.01, compared with group remifentanil-induced hyperalgesia (RIH); n = 6 rats in each group. PWL, paw withdrawal latency; PWT, paw withdrawal threshold.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232047&req=5

fig01: The effects of EphB1-Fc and MK-801 on mechanical allodynia (A) and thermal hyperalgesia (B) induced by remifentanil in rats. Data were shown as the mean ± standard deviation. **p < 0.01, compared with group CON; #p < 0.05, ##p < 0.01, compared with group remifentanil-induced hyperalgesia (RIH); n = 6 rats in each group. PWL, paw withdrawal latency; PWT, paw withdrawal threshold.
Mentions: At 2 h after plantar incision, a significant decrease in both mechanical and thermal nociceptive thresholds was observed (4.06 ± 0.95 g and 8.38 ± 1.50 s) compared with control group (7.83 ± 0.98 g and 11.34 ± 2.02 s). On day 1 after manipulation, remifentanil induced a significant decrease in both mechanical and thermal hypersensitivity (about 55% ± 3% and 41% ± 2%, respectively) (p < 0.01, group RIH compared with group CON, n = 6 per group; Fig. 1A and B).

Bottom Line: Continuing infusion of remifentanil produced a thermal hyperalgesia and mechanical allodynia, which was accompanied with increased protein expression of spinal-level EphB1 receptor, ephrinB1 ligand and Fos; what appeared above was suppressed by pretreatment with EphB1-Fc, an antagonist of ephrinB/EphB or MK-801, and increased pain behaviours induced by intrathecal injection of ephrinB1-Fc, an agonist of ephrinB/EphB, were suppressed by MK-801.Our findings indicated that ephrinB/EphB signalling is involved in RIH.EphrinB/EphB signalling might be the upstream of NMDA receptor.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Show MeSH
Related in: MedlinePlus