Spinal ephrinB/EphB signalling contributed to remifentanil-induced hyperalgesia via NMDA receptor.
Bottom Line: Continuing infusion of remifentanil produced a thermal hyperalgesia and mechanical allodynia, which was accompanied with increased protein expression of spinal-level EphB1 receptor, ephrinB1 ligand and Fos; what appeared above was suppressed by pretreatment with EphB1-Fc, an antagonist of ephrinB/EphB or MK-801, and increased pain behaviours induced by intrathecal injection of ephrinB1-Fc, an agonist of ephrinB/EphB, were suppressed by MK-801.Our findings indicated that ephrinB/EphB signalling is involved in RIH.EphrinB/EphB signalling might be the upstream of NMDA receptor.
Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.Show MeSH
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Mentions: At 2 h after plantar incision, a significant decrease in both mechanical and thermal nociceptive thresholds was observed (4.06 ± 0.95 g and 8.38 ± 1.50 s) compared with control group (7.83 ± 0.98 g and 11.34 ± 2.02 s). On day 1 after manipulation, remifentanil induced a significant decrease in both mechanical and thermal hypersensitivity (about 55% ± 3% and 41% ± 2%, respectively) (p < 0.01, group RIH compared with group CON, n = 6 per group; Fig. 1A and B).
Affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.