Tolerability of the capsaicin 8% patch following pretreatment with lidocaine or tramadol in patients with peripheral neuropathic pain: a multicentre, randomized, assessor-blinded study.
Bottom Line: Application of the capsaicin 8% patch is associated with treatment-related discomfort.Capsaicin 8% patch tolerability was similar in the two arms, with comparable results for most secondary endpoints.Tramadol given 30 min before patch application should be considered as an alternative pretreatment option in patients receiving capsaicin patch treatment.
Affiliation: Department of Neurology, Danish Pain Research Centre, Aarhus University Hospital, Denmark.Show MeSH
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Mentions: A similar proportion of patients receiving lidocaine reported an increase of ≥2 points from baseline in the NPRS ‘Pain Now’ score for at least one time point to the evening of the treatment visit compared with tramadol-treated patients (Fig. 4). The proportion of patients reporting an increase of >33% in NPRS ‘Pain Now’ score from baseline for at least one time point to the evening of the treatment visit was similar between treatment arms (Fig. 4). The proportion of patients reporting an increase of >33% in NPRS ‘Average Pain’ score from baseline to at least one subsequent time point up to day 3 was similar in the lidocaine and the tramadol arms (Fig. 5).
Affiliation: Department of Neurology, Danish Pain Research Centre, Aarhus University Hospital, Denmark.