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Tolerability of the capsaicin 8% patch following pretreatment with lidocaine or tramadol in patients with peripheral neuropathic pain: a multicentre, randomized, assessor-blinded study.

Jensen TS, Høye K, Fricová J, Vanelderen P, Ernault E, Siciliano T, Marques S - Eur J Pain (2014)

Bottom Line: Application of the capsaicin 8% patch is associated with treatment-related discomfort.Capsaicin 8% patch tolerability was similar in the two arms, with comparable results for most secondary endpoints.Tramadol given 30 min before patch application should be considered as an alternative pretreatment option in patients receiving capsaicin patch treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Danish Pain Research Centre, Aarhus University Hospital, Denmark.

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Related in: MedlinePlus

Study design.
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fig01: Study design.

Mentions: The LIFT study (registered at clinicaltrials.gov; NCT01416116) was a multicentre (Belgium, Czech Republic, Denmark, Great Britain, Ireland, Norway and Slovakia), randomized, assessor-blinded study conducted between July 2011 and April 2012. Patients were enrolled by the investigators, then randomly allocated, using randomization numbers and envelopes by staff at the study site, to one of two treatment arms in a 1:1 ratio. Subjects in arm 1 received application of topical anaesthetic cream (lidocaine 4%) to the area of pain, 70 min before patch application, for 60 min; those in arm 2 were administered oral tramadol 50 mg, 30 min before patch application. At the treatment visit, patients received their assigned pretreatment, followed by a 60-min application of the capsaicin 8% patch. After patch removal, patients were monitored for at least 2 h and then discharged (Fig. 1).


Tolerability of the capsaicin 8% patch following pretreatment with lidocaine or tramadol in patients with peripheral neuropathic pain: a multicentre, randomized, assessor-blinded study.

Jensen TS, Høye K, Fricová J, Vanelderen P, Ernault E, Siciliano T, Marques S - Eur J Pain (2014)

Study design.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232045&req=5

fig01: Study design.
Mentions: The LIFT study (registered at clinicaltrials.gov; NCT01416116) was a multicentre (Belgium, Czech Republic, Denmark, Great Britain, Ireland, Norway and Slovakia), randomized, assessor-blinded study conducted between July 2011 and April 2012. Patients were enrolled by the investigators, then randomly allocated, using randomization numbers and envelopes by staff at the study site, to one of two treatment arms in a 1:1 ratio. Subjects in arm 1 received application of topical anaesthetic cream (lidocaine 4%) to the area of pain, 70 min before patch application, for 60 min; those in arm 2 were administered oral tramadol 50 mg, 30 min before patch application. At the treatment visit, patients received their assigned pretreatment, followed by a 60-min application of the capsaicin 8% patch. After patch removal, patients were monitored for at least 2 h and then discharged (Fig. 1).

Bottom Line: Application of the capsaicin 8% patch is associated with treatment-related discomfort.Capsaicin 8% patch tolerability was similar in the two arms, with comparable results for most secondary endpoints.Tramadol given 30 min before patch application should be considered as an alternative pretreatment option in patients receiving capsaicin patch treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Danish Pain Research Centre, Aarhus University Hospital, Denmark.

Show MeSH
Related in: MedlinePlus