Allosteric control of the exportin CRM1 unraveled by crystal structure analysis.
Bottom Line: Moreover, during the last decade, CRM1 has become a more and more appreciated target for anti-cancer drugs.Hence, detailed understanding of the flexibility, the regulatory features and the positive binding cooperativity between CRM1, Ran and cargo is a prerequisite for the development of highly effective drugs.Here we review recent structural advances in the characterization of CRM1 and CRM1-containing complexes with a special emphasis on X-ray crystallographic studies.
Affiliation: Abteilung für Molekulare Strukturbiologie, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August-Universität Göttingen, Germany.Show MeSH
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Mentions: The available structural information on CRM1 and its various export and disassembly complexes allowed the deduction of a detailed flowchart with the gross overall movements as well as the important interaction sites with Ran, cargo and disassembly factors (RanBPs) in the individual steps of a CRM1 transport cycle (Fig.7).
Affiliation: Abteilung für Molekulare Strukturbiologie, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August-Universität Göttingen, Germany.