Heterogeneity in risk of pelvic inflammatory diseases after chlamydia infection: a population-based study in Manitoba, Canada.
Bottom Line: The increased risk of PID from reinfection was highest in younger individuals (AHR, 4.55 (95% CI, 3.59-5.78) in individuals aged 12-15 years at the time of their second reinfection, compared with individuals older than 30 years).There is heterogeneity in the risk of PID after a chlamydia infection.Describing the progression to PID in mathematical models as an average rate may be an oversimplification; more accurate estimates of the cost-effectiveness of screening may be obtained by using an individual-based measure of risk.
Affiliation: Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London.Show MeSH
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Mentions: The cohort contains 147 258 women and girls aged 12–24 years between 1992 and 1996; 72 883 (49.5%) were eligible for this analysis because they had been tested for chlamydia and did not have a recorded diagnosis of PID, pregnancy, or infertility before the date of their first chlamydia test in the cohort (Figure 1). These individuals contributed 625 621 person-years of follow-up before their 41st birthday, 31 December 2008, leaving Manitoba, or their first diagnosis of PID.Figure 1.
Affiliation: Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London.