Genome evolution and plasticity of Serratia marcescens, an important multidrug-resistant nosocomial pathogen.
Bottom Line: Naturally, it is found in many environmental niches, and is capable of infecting plants and animals.We further show that pSMC1 is most closely related to plasmids circulating in Pseudomonas species.Our data will provide a valuable basis for future studies on S. marcescens and new insights into the genetic mechanisms that underlie the emergence of pathogens highly resistant to multiple antimicrobial agents.
Affiliation: Interdisciplinary Research Organization, University of Miyazaki, JapanPresent address: Department of Animal and Grassland Sciences, Faculty of Agriculture, University of Miyazaki, Japan.Show MeSH
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Mentions: The gene cluster for O antigen biosynthesis was identified between the S-layer biosynthesis gene cluster and the his operon in both strains (fig. 4). As expected, the gene contents of the loci significantly differ between the two strains; Db11 was serotyped conventionally as O28:K7, whereas SM39 was untypeable. There is also good evidence from the genome sequences that both strains carry a complete gene cluster for group 1 capsule polysaccharide (CPS) biosynthesis, equivalent to the colanic acid biosynthesis genes in E. coli. Differences in gene content in this region suggest, however, that the two strains produce different types of group 1 CPS (fig. 4). This will need to be addressed experimentally in future studies.Fig. 4.—
Affiliation: Interdisciplinary Research Organization, University of Miyazaki, JapanPresent address: Department of Animal and Grassland Sciences, Faculty of Agriculture, University of Miyazaki, Japan.