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Extraneural Metastases of Glioblastoma without Simultaneous Central Nervous System Recurrence.

Kim W, Yoo H, Shin SH, Gwak HS, Lee SH - Brain Tumor Res Treat (2014)

Bottom Line: It could easily spread into the adjacent or distant brain tissue by infiltration, direct extension and cerebro-spinal fluid dissemination.The extranueural metastatic spread of GBM is relatively rare but it could have more progressive disease course.We report a 39-year-old man who had multiple bone metastases and malignant pleural effusion of the GBM without primary site recurrence.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.

ABSTRACT
Glioblastoma multiforme (GBM) is well known as the most common malignant primary brain tumor. It could easily spread into the adjacent or distant brain tissue by infiltration, direct extension and cerebro-spinal fluid dissemination. The extranueural metastatic spread of GBM is relatively rare but it could have more progressive disease course. We report a 39-year-old man who had multiple bone metastases and malignant pleural effusion of the GBM without primary site recurrence.

No MeSH data available.


Related in: MedlinePlus

A: Whole body fluorodeoxyglucose positron emission tomography scan imaging reveals multiple bone metastases to spine, ribs, pelvic, and scrum. B: Bone scan imaging shows multiple bone metastases in T-L spine and both ribs. C: Chest CT image reveals both malignant pleural effusion and both plural nodularity with focal chest wall invasion.
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Figure 4: A: Whole body fluorodeoxyglucose positron emission tomography scan imaging reveals multiple bone metastases to spine, ribs, pelvic, and scrum. B: Bone scan imaging shows multiple bone metastases in T-L spine and both ribs. C: Chest CT image reveals both malignant pleural effusion and both plural nodularity with focal chest wall invasion.

Mentions: Sudden severe back pain and lower extremity paraplegia occurred seven months after initial diagnosis of GBM. Spine magnetic resonance imaging (MRI) revealed compression fracture of sixth thoracic vertebra and epidural mass compressing spinal cord (Fig. 3), but there was no intracranial recurrence in brain MRI (Fig. 1C). Emergency decompressive laminectomy and epidural mass excision were performed. The pathologic diagnosis was suggestive of metastatic lesion of GBM (Fig. 2B). Additional multiple bone metastases in T-L spine, both ribs, both pelvic bones and right femur shaft were founded through whole body positron emission tomography and bone scan (Fig. 4). Also suspicious metastatic tumor cells were detected from pleural fluid. Excisional biopsy of the osteomyelitis-like lesion at head of left fourth rib proved it another metastatic GBM (Fig. 2C). The patient had uncontrolled malignant pleural effusion and rapid systemic aggravation. In spite of active mechanical ventilation and best supportive care in intensive care unit, he expired three months later.


Extraneural Metastases of Glioblastoma without Simultaneous Central Nervous System Recurrence.

Kim W, Yoo H, Shin SH, Gwak HS, Lee SH - Brain Tumor Res Treat (2014)

A: Whole body fluorodeoxyglucose positron emission tomography scan imaging reveals multiple bone metastases to spine, ribs, pelvic, and scrum. B: Bone scan imaging shows multiple bone metastases in T-L spine and both ribs. C: Chest CT image reveals both malignant pleural effusion and both plural nodularity with focal chest wall invasion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4231629&req=5

Figure 4: A: Whole body fluorodeoxyglucose positron emission tomography scan imaging reveals multiple bone metastases to spine, ribs, pelvic, and scrum. B: Bone scan imaging shows multiple bone metastases in T-L spine and both ribs. C: Chest CT image reveals both malignant pleural effusion and both plural nodularity with focal chest wall invasion.
Mentions: Sudden severe back pain and lower extremity paraplegia occurred seven months after initial diagnosis of GBM. Spine magnetic resonance imaging (MRI) revealed compression fracture of sixth thoracic vertebra and epidural mass compressing spinal cord (Fig. 3), but there was no intracranial recurrence in brain MRI (Fig. 1C). Emergency decompressive laminectomy and epidural mass excision were performed. The pathologic diagnosis was suggestive of metastatic lesion of GBM (Fig. 2B). Additional multiple bone metastases in T-L spine, both ribs, both pelvic bones and right femur shaft were founded through whole body positron emission tomography and bone scan (Fig. 4). Also suspicious metastatic tumor cells were detected from pleural fluid. Excisional biopsy of the osteomyelitis-like lesion at head of left fourth rib proved it another metastatic GBM (Fig. 2C). The patient had uncontrolled malignant pleural effusion and rapid systemic aggravation. In spite of active mechanical ventilation and best supportive care in intensive care unit, he expired three months later.

Bottom Line: It could easily spread into the adjacent or distant brain tissue by infiltration, direct extension and cerebro-spinal fluid dissemination.The extranueural metastatic spread of GBM is relatively rare but it could have more progressive disease course.We report a 39-year-old man who had multiple bone metastases and malignant pleural effusion of the GBM without primary site recurrence.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.

ABSTRACT
Glioblastoma multiforme (GBM) is well known as the most common malignant primary brain tumor. It could easily spread into the adjacent or distant brain tissue by infiltration, direct extension and cerebro-spinal fluid dissemination. The extranueural metastatic spread of GBM is relatively rare but it could have more progressive disease course. We report a 39-year-old man who had multiple bone metastases and malignant pleural effusion of the GBM without primary site recurrence.

No MeSH data available.


Related in: MedlinePlus