Limits...
Extraneural Metastases of Glioblastoma without Simultaneous Central Nervous System Recurrence.

Kim W, Yoo H, Shin SH, Gwak HS, Lee SH - Brain Tumor Res Treat (2014)

Bottom Line: It could easily spread into the adjacent or distant brain tissue by infiltration, direct extension and cerebro-spinal fluid dissemination.The extranueural metastatic spread of GBM is relatively rare but it could have more progressive disease course.We report a 39-year-old man who had multiple bone metastases and malignant pleural effusion of the GBM without primary site recurrence.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.

ABSTRACT
Glioblastoma multiforme (GBM) is well known as the most common malignant primary brain tumor. It could easily spread into the adjacent or distant brain tissue by infiltration, direct extension and cerebro-spinal fluid dissemination. The extranueural metastatic spread of GBM is relatively rare but it could have more progressive disease course. We report a 39-year-old man who had multiple bone metastases and malignant pleural effusion of the GBM without primary site recurrence.

No MeSH data available.


Related in: MedlinePlus

Histologic findings of tumor mass from brain (A), spine (B), and rib (C) show pleomorphic astrocytic tumor cells with mitosis and nuclear atypia compatible to glioblastoma (hematoxylin-eosin, original magnification, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4231629&req=5

Figure 2: Histologic findings of tumor mass from brain (A), spine (B), and rib (C) show pleomorphic astrocytic tumor cells with mitosis and nuclear atypia compatible to glioblastoma (hematoxylin-eosin, original magnification, ×400).

Mentions: A 39-year-old man presented with 2 weeks history of headache and visual disturbance. Magnetic resonance studies showed a huge multi-lobulated contoured necrotic enhancing mass in right parieto-occipital area (Fig. 1A). Under the presumptive diagnosis of high grade glioma, craniotomy and tumor removal was performed, and residual tumor was not observed on initial postoperative magnetic resonance images (Fig. 1B). The pathological diagnosis was GBM (Fig. 2A). The patient was treated using three-dimensional conformal radiotherapy (6,000 cGy, 240 cGy, 25 fraction) combined with temozolomide (TMZ, 75 mg/m2/day), and then 4 cycles of standard adjuvant TMZ (150 mg/m2/day during five days).


Extraneural Metastases of Glioblastoma without Simultaneous Central Nervous System Recurrence.

Kim W, Yoo H, Shin SH, Gwak HS, Lee SH - Brain Tumor Res Treat (2014)

Histologic findings of tumor mass from brain (A), spine (B), and rib (C) show pleomorphic astrocytic tumor cells with mitosis and nuclear atypia compatible to glioblastoma (hematoxylin-eosin, original magnification, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4231629&req=5

Figure 2: Histologic findings of tumor mass from brain (A), spine (B), and rib (C) show pleomorphic astrocytic tumor cells with mitosis and nuclear atypia compatible to glioblastoma (hematoxylin-eosin, original magnification, ×400).
Mentions: A 39-year-old man presented with 2 weeks history of headache and visual disturbance. Magnetic resonance studies showed a huge multi-lobulated contoured necrotic enhancing mass in right parieto-occipital area (Fig. 1A). Under the presumptive diagnosis of high grade glioma, craniotomy and tumor removal was performed, and residual tumor was not observed on initial postoperative magnetic resonance images (Fig. 1B). The pathological diagnosis was GBM (Fig. 2A). The patient was treated using three-dimensional conformal radiotherapy (6,000 cGy, 240 cGy, 25 fraction) combined with temozolomide (TMZ, 75 mg/m2/day), and then 4 cycles of standard adjuvant TMZ (150 mg/m2/day during five days).

Bottom Line: It could easily spread into the adjacent or distant brain tissue by infiltration, direct extension and cerebro-spinal fluid dissemination.The extranueural metastatic spread of GBM is relatively rare but it could have more progressive disease course.We report a 39-year-old man who had multiple bone metastases and malignant pleural effusion of the GBM without primary site recurrence.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.

ABSTRACT
Glioblastoma multiforme (GBM) is well known as the most common malignant primary brain tumor. It could easily spread into the adjacent or distant brain tissue by infiltration, direct extension and cerebro-spinal fluid dissemination. The extranueural metastatic spread of GBM is relatively rare but it could have more progressive disease course. We report a 39-year-old man who had multiple bone metastases and malignant pleural effusion of the GBM without primary site recurrence.

No MeSH data available.


Related in: MedlinePlus