Limits...
Adult-onset sellar and suprasellar atypical teratoid rhabdoid tumor treated with a multimodal approach: a case report.

Park HG, Yoon JH, Kim SH, Cho KH, Park HJ, Kim SH, Kim EH - Brain Tumor Res Treat (2014)

Bottom Line: After surgery, she received radiotherapy including spinal irradiation with proton beam therapy and subsequent chemotherapy, with no evidence of recurrence for more than 2 years.Up to date, this is the 8th case of an adult-onset ATRT in the sellar or suprasellar region.Despite its rarity, ATRTs should be considered in the differential diagnosis of an unclear malignant sellar or suprasellar lesion in adult patients and the treatment strategies for adult ATRT patients could be differentiated from those of pediatric ATRT patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
We report a very rare case of sellar and suprasellar atypical teratoid rhabdoid tumor (ATRT) in a 42-year-old female patient. The tumor was removed subtotally with a transsphenoidal approach. Histopathologic study showed rhabdoid cells with prominent nucleoli and abundant cytoplasm. Immunohistochemistry for INI1 was completely negative in the tumor cells, consistent with ATRT. After surgery, she received radiotherapy including spinal irradiation with proton beam therapy and subsequent chemotherapy, with no evidence of recurrence for more than 2 years. Up to date, this is the 8th case of an adult-onset ATRT in the sellar or suprasellar region. Despite its rarity, ATRTs should be considered in the differential diagnosis of an unclear malignant sellar or suprasellar lesion in adult patients and the treatment strategies for adult ATRT patients could be differentiated from those of pediatric ATRT patients.

No MeSH data available.


Related in: MedlinePlus

Preoperative magnetic resonance imaging shows a heterogeneously enhanced mass involving the sella in a T1-weighted gadolinium-enhanced coronal (A) and sagittal view (B). T2-weighted coronal (C) and sagittal (D) images reveals solid and cystic components of the tumor with compression of an optic apparatus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4231618&req=5

Figure 1: Preoperative magnetic resonance imaging shows a heterogeneously enhanced mass involving the sella in a T1-weighted gadolinium-enhanced coronal (A) and sagittal view (B). T2-weighted coronal (C) and sagittal (D) images reveals solid and cystic components of the tumor with compression of an optic apparatus.

Mentions: A 42-year-old female patient presented with progressive visual disturbance. She did not have any other medical history before but hypertension and pulmonary tuberculosis. Humphrey test revealed defect of more than three quarters of her bilateral visual field. No other neurologic deficits were found. Preoperative magnetic resonance imaging (MRI) showed a heterogeneously enhanced solid and cystic mass involving the sella and suprasellar region with compression of an optic apparatus (Fig. 1). The solid part of the tumor showed isointense signal with heterogeneous enhancement on T1-weighted images and slightly hyperintensity on T2-weighted images.


Adult-onset sellar and suprasellar atypical teratoid rhabdoid tumor treated with a multimodal approach: a case report.

Park HG, Yoon JH, Kim SH, Cho KH, Park HJ, Kim SH, Kim EH - Brain Tumor Res Treat (2014)

Preoperative magnetic resonance imaging shows a heterogeneously enhanced mass involving the sella in a T1-weighted gadolinium-enhanced coronal (A) and sagittal view (B). T2-weighted coronal (C) and sagittal (D) images reveals solid and cystic components of the tumor with compression of an optic apparatus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4231618&req=5

Figure 1: Preoperative magnetic resonance imaging shows a heterogeneously enhanced mass involving the sella in a T1-weighted gadolinium-enhanced coronal (A) and sagittal view (B). T2-weighted coronal (C) and sagittal (D) images reveals solid and cystic components of the tumor with compression of an optic apparatus.
Mentions: A 42-year-old female patient presented with progressive visual disturbance. She did not have any other medical history before but hypertension and pulmonary tuberculosis. Humphrey test revealed defect of more than three quarters of her bilateral visual field. No other neurologic deficits were found. Preoperative magnetic resonance imaging (MRI) showed a heterogeneously enhanced solid and cystic mass involving the sella and suprasellar region with compression of an optic apparatus (Fig. 1). The solid part of the tumor showed isointense signal with heterogeneous enhancement on T1-weighted images and slightly hyperintensity on T2-weighted images.

Bottom Line: After surgery, she received radiotherapy including spinal irradiation with proton beam therapy and subsequent chemotherapy, with no evidence of recurrence for more than 2 years.Up to date, this is the 8th case of an adult-onset ATRT in the sellar or suprasellar region.Despite its rarity, ATRTs should be considered in the differential diagnosis of an unclear malignant sellar or suprasellar lesion in adult patients and the treatment strategies for adult ATRT patients could be differentiated from those of pediatric ATRT patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
We report a very rare case of sellar and suprasellar atypical teratoid rhabdoid tumor (ATRT) in a 42-year-old female patient. The tumor was removed subtotally with a transsphenoidal approach. Histopathologic study showed rhabdoid cells with prominent nucleoli and abundant cytoplasm. Immunohistochemistry for INI1 was completely negative in the tumor cells, consistent with ATRT. After surgery, she received radiotherapy including spinal irradiation with proton beam therapy and subsequent chemotherapy, with no evidence of recurrence for more than 2 years. Up to date, this is the 8th case of an adult-onset ATRT in the sellar or suprasellar region. Despite its rarity, ATRTs should be considered in the differential diagnosis of an unclear malignant sellar or suprasellar lesion in adult patients and the treatment strategies for adult ATRT patients could be differentiated from those of pediatric ATRT patients.

No MeSH data available.


Related in: MedlinePlus