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Isolated central nervous system relapse of acute lymphoblastic leukemia.

Sung SH, Jang IS - Brain Tumor Res Treat (2014)

Bottom Line: Neurological examination revealed left-side homonymous hemianopsia.Surgery to remove the hematoma revealed the existence of hematopoietic malignancy after pathologic evaluation.Bone marrow biopsy was subsequently performed but showed no evidence of malignancy.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Science, Seoul, Korea.

ABSTRACT
Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer and may exhibit central nervous system (CNS) involvement. Advances in chemotherapy and effective CNS prophylaxis have significantly decreased the incidence of CNS relapse of ALL to 5-10%. Here, we report the case of a patient with isolated CNS relapse of standard risk group pre-B-cell type ALL in an 11-year-old girl, relapsed 3 years after successful completion of chemotherapy. An 11-year-old girl visited our hospital complaining of headache, dizziness, vomiting, and visual field defects. Neurological examination revealed left-side homonymous hemianopsia. Brain magnetic resonance imaging showed a large irregular dural-based sulcal hematoma in the right parietal and occipital lobes. Surgery to remove the hematoma revealed the existence of hematopoietic malignancy after pathologic evaluation. Bone marrow biopsy was subsequently performed but showed no evidence of malignancy.

No MeSH data available.


Related in: MedlinePlus

Brain magnetic resonance imaging demonstrated a low-intensity lesion on both T1- (A) and T2- (B) weighted images that appeared to be a sulcal hematoma. Gadolinium-enhanced T1-weighted imaging (C) showed a heterogeneously enhanced dural-based mass-like lesion and sulcal enhancement.
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Figure 2: Brain magnetic resonance imaging demonstrated a low-intensity lesion on both T1- (A) and T2- (B) weighted images that appeared to be a sulcal hematoma. Gadolinium-enhanced T1-weighted imaging (C) showed a heterogeneously enhanced dural-based mass-like lesion and sulcal enhancement.

Mentions: Brain magnetic resonance imaging demonstrated a low-intensity lesion on both T1- and T2-weighted images that appeared to be a sulcal hematoma. Gadolinium-enhanced T1-weighted imaging showed a heterogeneously enhanced dural-based mass-like lesion and sulcal enhancement (Fig. 2).


Isolated central nervous system relapse of acute lymphoblastic leukemia.

Sung SH, Jang IS - Brain Tumor Res Treat (2014)

Brain magnetic resonance imaging demonstrated a low-intensity lesion on both T1- (A) and T2- (B) weighted images that appeared to be a sulcal hematoma. Gadolinium-enhanced T1-weighted imaging (C) showed a heterogeneously enhanced dural-based mass-like lesion and sulcal enhancement.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4231617&req=5

Figure 2: Brain magnetic resonance imaging demonstrated a low-intensity lesion on both T1- (A) and T2- (B) weighted images that appeared to be a sulcal hematoma. Gadolinium-enhanced T1-weighted imaging (C) showed a heterogeneously enhanced dural-based mass-like lesion and sulcal enhancement.
Mentions: Brain magnetic resonance imaging demonstrated a low-intensity lesion on both T1- and T2-weighted images that appeared to be a sulcal hematoma. Gadolinium-enhanced T1-weighted imaging showed a heterogeneously enhanced dural-based mass-like lesion and sulcal enhancement (Fig. 2).

Bottom Line: Neurological examination revealed left-side homonymous hemianopsia.Surgery to remove the hematoma revealed the existence of hematopoietic malignancy after pathologic evaluation.Bone marrow biopsy was subsequently performed but showed no evidence of malignancy.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Science, Seoul, Korea.

ABSTRACT
Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer and may exhibit central nervous system (CNS) involvement. Advances in chemotherapy and effective CNS prophylaxis have significantly decreased the incidence of CNS relapse of ALL to 5-10%. Here, we report the case of a patient with isolated CNS relapse of standard risk group pre-B-cell type ALL in an 11-year-old girl, relapsed 3 years after successful completion of chemotherapy. An 11-year-old girl visited our hospital complaining of headache, dizziness, vomiting, and visual field defects. Neurological examination revealed left-side homonymous hemianopsia. Brain magnetic resonance imaging showed a large irregular dural-based sulcal hematoma in the right parietal and occipital lobes. Surgery to remove the hematoma revealed the existence of hematopoietic malignancy after pathologic evaluation. Bone marrow biopsy was subsequently performed but showed no evidence of malignancy.

No MeSH data available.


Related in: MedlinePlus