Limits...
Evaluation of potassium clavulanate on ethanol consumption and decision making in the model of ethanol dependence in mice.

Jadhav KS, Marathe PA - J Pharmacol Pharmacother (2014)

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Therapeutics, Seth GS Medical College, KEM Hospital, Parel, Mumbai, Maharashtra, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

However, use of any antibiotic for a prolonged period of time for decreasing ethanol consumption may lead to the development of antibiotic resistance... Hence, an ideal agent would be one which has both, the beta-lactam ring and no antibiotic effect... Mice in the naltrexone, potassium clavulanate, and combination group showed a significantly lesser intake of absolute ethanol as compared to control with the combination group showing the least intake of 3.27 ± 1.28 g/kg/day... The combination group showed a statistically significant lower intake of absolute ethanol when compared to the naltrexone group (7.46 ± 3.34 g/kg/day) and the potassium clavulanate group (9.81 ± 2.71 g/kg/day)... The mice in the naltrexone, potassium clavulanate and combination group showed a significantly lesser percentage of ethanol preference when compared to control with the combination group showing the least preference of 26.59 ± 11.76%... The combination group showed a statistically significant lower percentage of ethanol preference when compared to the naltrexone group (51.65 ± 11.77%) and the potassium clavulanate (58.05 ± 12.24%) which showed intake of absolute ethanol... The observations of the mice in the naltrexone group were comparable statistically to those mice in potassium clavulanate group... Furthermore, the combination group showed statistically comparable results to the naltrexone and the clavulanate groups... One can hypothesize that potassium clavulanate increases serotonin levels in the CNS, which improves decision taking abilities of alcohol dependent mice... Zeeb et al. have shown that 5-hydroxytryptamine 1A receptor agonist, 8-hydroxy-N, N-dipropyl-2-aminotetralin, which decreases presynaptic serotonin release impaired decision taking on IGT.

No MeSH data available.


Rodent model of Iowa gambling task
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4231555&req=5

Figure 2: Rodent model of Iowa gambling task

Mentions: The mice in the control group exhibited intake of absolute ethanol of 20.09 ± 1.25 g/kg/day [Figure 2]. Mice in the naltrexone, potassium clavulanate, and combination group showed a significantly lesser intake of absolute ethanol as compared to control with the combination group showing the least intake of 3.27 ± 1.28 g/kg/day. The combination group showed a statistically significant lower intake of absolute ethanol when compared to the naltrexone group (7.46 ± 3.34 g/kg/day) and the potassium clavulanate group (9.81 ± 2.71 g/kg/day). Thus the combination of naltrexone + potassium clavulanate showed lower ethanol intake when compared to the individual drugs. The intake of absolute ethanol in the potassium clavulanate group was statistically comparable to the naltrexone group. Water intake in all the groups was comparable to each other which show that potassium clavulanate selectively decreased the intake of ethanol without affecting water.


Evaluation of potassium clavulanate on ethanol consumption and decision making in the model of ethanol dependence in mice.

Jadhav KS, Marathe PA - J Pharmacol Pharmacother (2014)

Rodent model of Iowa gambling task
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4231555&req=5

Figure 2: Rodent model of Iowa gambling task
Mentions: The mice in the control group exhibited intake of absolute ethanol of 20.09 ± 1.25 g/kg/day [Figure 2]. Mice in the naltrexone, potassium clavulanate, and combination group showed a significantly lesser intake of absolute ethanol as compared to control with the combination group showing the least intake of 3.27 ± 1.28 g/kg/day. The combination group showed a statistically significant lower intake of absolute ethanol when compared to the naltrexone group (7.46 ± 3.34 g/kg/day) and the potassium clavulanate group (9.81 ± 2.71 g/kg/day). Thus the combination of naltrexone + potassium clavulanate showed lower ethanol intake when compared to the individual drugs. The intake of absolute ethanol in the potassium clavulanate group was statistically comparable to the naltrexone group. Water intake in all the groups was comparable to each other which show that potassium clavulanate selectively decreased the intake of ethanol without affecting water.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Therapeutics, Seth GS Medical College, KEM Hospital, Parel, Mumbai, Maharashtra, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

However, use of any antibiotic for a prolonged period of time for decreasing ethanol consumption may lead to the development of antibiotic resistance... Hence, an ideal agent would be one which has both, the beta-lactam ring and no antibiotic effect... Mice in the naltrexone, potassium clavulanate, and combination group showed a significantly lesser intake of absolute ethanol as compared to control with the combination group showing the least intake of 3.27 ± 1.28 g/kg/day... The combination group showed a statistically significant lower intake of absolute ethanol when compared to the naltrexone group (7.46 ± 3.34 g/kg/day) and the potassium clavulanate group (9.81 ± 2.71 g/kg/day)... The mice in the naltrexone, potassium clavulanate and combination group showed a significantly lesser percentage of ethanol preference when compared to control with the combination group showing the least preference of 26.59 ± 11.76%... The combination group showed a statistically significant lower percentage of ethanol preference when compared to the naltrexone group (51.65 ± 11.77%) and the potassium clavulanate (58.05 ± 12.24%) which showed intake of absolute ethanol... The observations of the mice in the naltrexone group were comparable statistically to those mice in potassium clavulanate group... Furthermore, the combination group showed statistically comparable results to the naltrexone and the clavulanate groups... One can hypothesize that potassium clavulanate increases serotonin levels in the CNS, which improves decision taking abilities of alcohol dependent mice... Zeeb et al. have shown that 5-hydroxytryptamine 1A receptor agonist, 8-hydroxy-N, N-dipropyl-2-aminotetralin, which decreases presynaptic serotonin release impaired decision taking on IGT.

No MeSH data available.