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Preeclampsia is associated with increased maternal body weight in a northeastern Brazilian population.

Dantas EM, Pereira FV, Queiroz JW, Dantas DL, Monteiro GR, Duggal P, Azevedo Mde F, Jeronimo SM, Araújo AC - BMC Pregnancy Childbirth (2013)

Bottom Line: The mortality is higher in lower income countries, where it is the leading cause of maternal mortality.This latter group was considered the normotensive controls.Therefore, effective preventive measures are needed, particularly women at lower social economic stratum who have less access to proper medical care and adequate nutrition.

View Article: PubMed Central - HTML - PubMed

Affiliation: Health Sciences Post-Graduate Program, Natal, RN, Brazil. crysaraujo@uol.com.br.

ABSTRACT

Background: Preeclampsia is a disease with great variability in incidence across the world. The mortality is higher in lower income countries, where it is the leading cause of maternal mortality. This study aimed to determine the frequency of and risk factors for preeclampsia in a low income population from an urban area of Brazil.

Methods: A prospective case control study of 242 women of which 30 developed preeclampsia, 4 had gestational hypertension, 2 had superimposed hypertension, 11 had spontaneous abortion, 13 were lost to follow up and 192 had normal pregnancy. This latter group was considered the normotensive controls. The rate of preeclampsia and the risk of cardiovascular disease, after onset of preeclampsia, were determined.

Results: Of the 218 women who completed the study, the frequency of hypertensive disorder of pregnancy was 16.5% (36 of 218) and of preeclampsia was 13.8% (30 of 218). Women with preeclampsia had a higher body mass index (BMI), mean of 25.3 ± 4.8 compared to 23.5 ± 3.7 for the normotensive controls, p = 0.02. The risk of preeclampsia increased with BMI [Odds ratio (OR) 1.12, 95% Confidence Interval (CI = 1.02;1.24, p-value = 0.023)]. Women with preeclampsia developed chronic hypertension more often than normotensive controls (p = 0.043) and their systolic and ambulatory blood pressure monitoring was elevated (p = 0.034). Women with preeclampsia had higher BMI even 5 years post-pregnancy (p = 0.008).

Conclusions: Women who are overweight or older have an increased risk of preeclampsia. Previous history of preeclampsia increases the risk of early onset of chronic hypertension. Therefore, effective preventive measures are needed, particularly women at lower social economic stratum who have less access to proper medical care and adequate nutrition.

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The percent of women with hypertensive disorder of pregnancy versus body mass index. X axis represents BMI by interval and Y axis represents the percent of women with hypertensive disorder of pregnancy per interval of BMI.
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Figure 3: The percent of women with hypertensive disorder of pregnancy versus body mass index. X axis represents BMI by interval and Y axis represents the percent of women with hypertensive disorder of pregnancy per interval of BMI.

Mentions: No association with family history of hypertension or preeclampsia was observed (Table 1). The risk of preeclampsia increased exponentially with age, (6% increase risk per year, p = 0.090), and as represented in Figure 2, and with BMI (12% increase risk for each unit of increased BMI, p = 0.023), determined by using a binary logistic model corrected by age and BMI, (Table 2), Figure 3. The level of schooling was lower in women with preeclampsia, with only 20% having completed high school (p = 0.025).


Preeclampsia is associated with increased maternal body weight in a northeastern Brazilian population.

Dantas EM, Pereira FV, Queiroz JW, Dantas DL, Monteiro GR, Duggal P, Azevedo Mde F, Jeronimo SM, Araújo AC - BMC Pregnancy Childbirth (2013)

The percent of women with hypertensive disorder of pregnancy versus body mass index. X axis represents BMI by interval and Y axis represents the percent of women with hypertensive disorder of pregnancy per interval of BMI.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4231463&req=5

Figure 3: The percent of women with hypertensive disorder of pregnancy versus body mass index. X axis represents BMI by interval and Y axis represents the percent of women with hypertensive disorder of pregnancy per interval of BMI.
Mentions: No association with family history of hypertension or preeclampsia was observed (Table 1). The risk of preeclampsia increased exponentially with age, (6% increase risk per year, p = 0.090), and as represented in Figure 2, and with BMI (12% increase risk for each unit of increased BMI, p = 0.023), determined by using a binary logistic model corrected by age and BMI, (Table 2), Figure 3. The level of schooling was lower in women with preeclampsia, with only 20% having completed high school (p = 0.025).

Bottom Line: The mortality is higher in lower income countries, where it is the leading cause of maternal mortality.This latter group was considered the normotensive controls.Therefore, effective preventive measures are needed, particularly women at lower social economic stratum who have less access to proper medical care and adequate nutrition.

View Article: PubMed Central - HTML - PubMed

Affiliation: Health Sciences Post-Graduate Program, Natal, RN, Brazil. crysaraujo@uol.com.br.

ABSTRACT

Background: Preeclampsia is a disease with great variability in incidence across the world. The mortality is higher in lower income countries, where it is the leading cause of maternal mortality. This study aimed to determine the frequency of and risk factors for preeclampsia in a low income population from an urban area of Brazil.

Methods: A prospective case control study of 242 women of which 30 developed preeclampsia, 4 had gestational hypertension, 2 had superimposed hypertension, 11 had spontaneous abortion, 13 were lost to follow up and 192 had normal pregnancy. This latter group was considered the normotensive controls. The rate of preeclampsia and the risk of cardiovascular disease, after onset of preeclampsia, were determined.

Results: Of the 218 women who completed the study, the frequency of hypertensive disorder of pregnancy was 16.5% (36 of 218) and of preeclampsia was 13.8% (30 of 218). Women with preeclampsia had a higher body mass index (BMI), mean of 25.3 ± 4.8 compared to 23.5 ± 3.7 for the normotensive controls, p = 0.02. The risk of preeclampsia increased with BMI [Odds ratio (OR) 1.12, 95% Confidence Interval (CI = 1.02;1.24, p-value = 0.023)]. Women with preeclampsia developed chronic hypertension more often than normotensive controls (p = 0.043) and their systolic and ambulatory blood pressure monitoring was elevated (p = 0.034). Women with preeclampsia had higher BMI even 5 years post-pregnancy (p = 0.008).

Conclusions: Women who are overweight or older have an increased risk of preeclampsia. Previous history of preeclampsia increases the risk of early onset of chronic hypertension. Therefore, effective preventive measures are needed, particularly women at lower social economic stratum who have less access to proper medical care and adequate nutrition.

Show MeSH
Related in: MedlinePlus