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SEPP1 gene variants and abdominal aortic aneurysm: gene association in relation to metabolic risk factors and peripheral arterial disease coexistence.

Strauss E, Oszkinis G, Staniszewski R - Sci Rep (2014)

Bottom Line: The other SEPP1 variants were associated with BMI values and influenced the risk of aortic diseases, depending on body weight.The strongest associations in the case-control analysis was found between the presence of the rs3877899G-rs7579G haplotype and development of AAA in overweight and obese subjects (OR = 1.80, 95%CI = 1.16-2.79, P = .008).Our results suggests the potential role of the selenoprotein P in pathogenesis of AAA.

View Article: PubMed Central - PubMed

Affiliation: 1] Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 Poznan, Poland [2] Department of General and Vascular Surgery, Poznan University of Medical Sciences, Dluga 1/2, 61-848 Poznan, Poland.

ABSTRACT
An inadequate selenium level is supposed to be a risk factor for cardiovascular diseases. However little is known about variation of the genes encoding selenium-containing proteins that would confirm the causality in these diseases. The aim of this study was to analyze the relationships between two functional variants of selenoprotein P gene (SEPP1 rs3877899G>A, rs7579G>A) and the occurrence of abdominal aortic aneurysm (AAA) and aortoiliac occlusive disease (AIOD), as well as their metabolic risk factors. In AAA, the rs3877899A allele was associated with higher systolic blood (P < .003) and pulse pressure (P < .003) values (recessive model), and with coexistence of peripheral arterial disease (PAD; carriers: P = .033). The other SEPP1 variants were associated with BMI values and influenced the risk of aortic diseases, depending on body weight. The strongest associations in the case-control analysis was found between the presence of the rs3877899G-rs7579G haplotype and development of AAA in overweight and obese subjects (OR = 1.80, 95%CI = 1.16-2.79, P = .008). The higher BMI values were correlated with lower age of AAA patients and larger size of aneurysm. Our results suggests the potential role of the selenoprotein P in pathogenesis of AAA. Future studies should consider the role of the rs3877899G-rs7579G haplotype as a risk factor for aggressive-growing AAAs.

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Related in: MedlinePlus

Influence of the SEPP1 rs3877899-rs7579 haplotypes on systolic blood pressure (SBP), pulse pressure (PP) parameters and body mass index (BMI) values in patients with abdominal aortic aneurysm (AAA).The x-axis indicates the number of haplotypes in patients.
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f1: Influence of the SEPP1 rs3877899-rs7579 haplotypes on systolic blood pressure (SBP), pulse pressure (PP) parameters and body mass index (BMI) values in patients with abdominal aortic aneurysm (AAA).The x-axis indicates the number of haplotypes in patients.

Mentions: The relations between SEPP1rs3877899-rs7579 haplotypes and age, sex, smoking status, blood pressure parameters, arterial hypertension, glucose levels, diabetes, BMI values, overweight, obesity, blood lipid, and lipoproteins level in AAA and AIOD were investigated. The associations of the specific SEPP1 haplotypes with blood pressure parameters, BMI values and occurrence of overweight and obesity (BMI > 25) were found (Figure 1, Tables 3 and 4). In AAA, carriers of two copies of the A-G haplotype had significantly higher systolic blood pressure (SBP) and pulse pressure (PP) values, as compared to subjects with one copy of this haplotype and to non-carriers (these effects remained also significant after adjusting for other potential confounders: age, sex, hypertension and PAD). The G-G haplotype was associated with higher, while G–A – with lower BMI values in this patient group (Figure 1). Carriers of the G-G haplotype had more frequently BMI values > 25 in the whole studied population (two copies: OR = 1.51, 95%CI = 1.11–2.06, P = .007), and display a significant 1.80-fold increase in risk for the development of AAA in overweight and obese subjects (dominant model, 95%CI: 1.16–2.79, P = .008). In patients group (AAA plus AIOD), carriers of the G-A haplotype had less frequently BMI values > 25 (OR = 0.69, 95% CI = 0.50–0.93, P = 0.016) and display a 1.54-fold increase in the risk of studied aortic diseases in non-overweight subjects (95%CI: 1.01–2.351, P = .045). These relationships remained significant after adjusting for age and sex. The associations of the A–G haplotype with aortic diseases in overweight and obese subjects were significant only in univariate analysis.


SEPP1 gene variants and abdominal aortic aneurysm: gene association in relation to metabolic risk factors and peripheral arterial disease coexistence.

Strauss E, Oszkinis G, Staniszewski R - Sci Rep (2014)

Influence of the SEPP1 rs3877899-rs7579 haplotypes on systolic blood pressure (SBP), pulse pressure (PP) parameters and body mass index (BMI) values in patients with abdominal aortic aneurysm (AAA).The x-axis indicates the number of haplotypes in patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4231327&req=5

f1: Influence of the SEPP1 rs3877899-rs7579 haplotypes on systolic blood pressure (SBP), pulse pressure (PP) parameters and body mass index (BMI) values in patients with abdominal aortic aneurysm (AAA).The x-axis indicates the number of haplotypes in patients.
Mentions: The relations between SEPP1rs3877899-rs7579 haplotypes and age, sex, smoking status, blood pressure parameters, arterial hypertension, glucose levels, diabetes, BMI values, overweight, obesity, blood lipid, and lipoproteins level in AAA and AIOD were investigated. The associations of the specific SEPP1 haplotypes with blood pressure parameters, BMI values and occurrence of overweight and obesity (BMI > 25) were found (Figure 1, Tables 3 and 4). In AAA, carriers of two copies of the A-G haplotype had significantly higher systolic blood pressure (SBP) and pulse pressure (PP) values, as compared to subjects with one copy of this haplotype and to non-carriers (these effects remained also significant after adjusting for other potential confounders: age, sex, hypertension and PAD). The G-G haplotype was associated with higher, while G–A – with lower BMI values in this patient group (Figure 1). Carriers of the G-G haplotype had more frequently BMI values > 25 in the whole studied population (two copies: OR = 1.51, 95%CI = 1.11–2.06, P = .007), and display a significant 1.80-fold increase in risk for the development of AAA in overweight and obese subjects (dominant model, 95%CI: 1.16–2.79, P = .008). In patients group (AAA plus AIOD), carriers of the G-A haplotype had less frequently BMI values > 25 (OR = 0.69, 95% CI = 0.50–0.93, P = 0.016) and display a 1.54-fold increase in the risk of studied aortic diseases in non-overweight subjects (95%CI: 1.01–2.351, P = .045). These relationships remained significant after adjusting for age and sex. The associations of the A–G haplotype with aortic diseases in overweight and obese subjects were significant only in univariate analysis.

Bottom Line: The other SEPP1 variants were associated with BMI values and influenced the risk of aortic diseases, depending on body weight.The strongest associations in the case-control analysis was found between the presence of the rs3877899G-rs7579G haplotype and development of AAA in overweight and obese subjects (OR = 1.80, 95%CI = 1.16-2.79, P = .008).Our results suggests the potential role of the selenoprotein P in pathogenesis of AAA.

View Article: PubMed Central - PubMed

Affiliation: 1] Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 Poznan, Poland [2] Department of General and Vascular Surgery, Poznan University of Medical Sciences, Dluga 1/2, 61-848 Poznan, Poland.

ABSTRACT
An inadequate selenium level is supposed to be a risk factor for cardiovascular diseases. However little is known about variation of the genes encoding selenium-containing proteins that would confirm the causality in these diseases. The aim of this study was to analyze the relationships between two functional variants of selenoprotein P gene (SEPP1 rs3877899G>A, rs7579G>A) and the occurrence of abdominal aortic aneurysm (AAA) and aortoiliac occlusive disease (AIOD), as well as their metabolic risk factors. In AAA, the rs3877899A allele was associated with higher systolic blood (P < .003) and pulse pressure (P < .003) values (recessive model), and with coexistence of peripheral arterial disease (PAD; carriers: P = .033). The other SEPP1 variants were associated with BMI values and influenced the risk of aortic diseases, depending on body weight. The strongest associations in the case-control analysis was found between the presence of the rs3877899G-rs7579G haplotype and development of AAA in overweight and obese subjects (OR = 1.80, 95%CI = 1.16-2.79, P = .008). The higher BMI values were correlated with lower age of AAA patients and larger size of aneurysm. Our results suggests the potential role of the selenoprotein P in pathogenesis of AAA. Future studies should consider the role of the rs3877899G-rs7579G haplotype as a risk factor for aggressive-growing AAAs.

Show MeSH
Related in: MedlinePlus