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Effects of acute treatment with a tryptophan-rich protein hydrolysate on plasma amino acids, mood and emotional functioning in older women.

Gibson EL, Vargas K, Hogan E, Holmes A, Rogers PJ, Wittwer J, Kloek J, Goralczyk R, Mohajeri MH - Psychopharmacology (Berl.) (2014)

Bottom Line: This treatment dose resulted in a significant shift in emotional processing towards positive words and reduced negative bias in assessing negative facial expressions.However, there was no evidence for any adverse effects.Consumption of a low dose of TRP-rich protein hydrolysate may have beneficial effects on emotional function that could promote feelings of wellbeing, possibly conferring resistance to deterioration in mood in healthy subjects or depressive episodes.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Whitelands College, University of Roehampton, Holybourne Avenue, London, SW15 4JD, UK, l.gibson@roehampton.ac.uk.

ABSTRACT

Rationale: Effective functioning of the neurotransmitter serotonin is important for optimal cognitive and emotional function. Dietary supplements able to increase availability to the brain of the precursor amino acid, tryptophan (TRP), and thereby enhance serotonin synthesis, can have measurable impact on these psychological processes.

Objectives: This study involves a randomised controlled trial of a TRP-rich egg-white protein hydrolysate (DSM Nutritional Products Ltd., Switzerland) on plasma amino acids, cognition, mood and emotional processing in older women.

Methods: Following a baseline test day without treatment, 60 healthy women aged 45-65 years received drinks containing either 2 or 4 g of TRP-rich protein hydrolysate product or 3.11 g casein hydrolysate as a control. One hour later, they undertook a 2-h battery of cognitive and emotional tests.

Results: The TRP-rich protein hydrolysate produced the expected dose-dependent increase in the ratio of plasma TRP to competing large neutral amino acids. TRP-rich protein hydrolysate (2 g only) prevented both the decline in wellbeing and increase in fatigue seen over the test session in the control group. This treatment dose resulted in a significant shift in emotional processing towards positive words and reduced negative bias in assessing negative facial expressions. Effects on cognition were small and not statistically reliable and are not reported here. However, there was no evidence for any adverse effects.

Conclusions: Consumption of a low dose of TRP-rich protein hydrolysate may have beneficial effects on emotional function that could promote feelings of wellbeing, possibly conferring resistance to deterioration in mood in healthy subjects or depressive episodes.

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Related in: MedlinePlus

Effect of LumiVida™ on latencies to respond to positive target words (with negative or neutral distractor words; all trials). Both doses of LumiVida™ (hashed column = 2 g; solid column = 4 g) reduced the response latency, *p < 0.05 vs. control (open column). Means are adjusted for baseline performance, age and NART errors
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Fig5: Effect of LumiVida™ on latencies to respond to positive target words (with negative or neutral distractor words; all trials). Both doses of LumiVida™ (hashed column = 2 g; solid column = 4 g) reduced the response latency, *p < 0.05 vs. control (open column). Means are adjusted for baseline performance, age and NART errors

Mentions: It was predicted that participants would respond faster to positive words with negative or neutral distractors after LumiVida™ if the treatment reduced bias to negative stimuli. For both doses, LumiVida™ reduced the latency to respond to positive words, i.e. faster reactions, ANCOVA group effect, F(2, 53) = 3.05, p < 0.03 one tail, ηp2 = 0.10; contrasts, 2 g vs. control, p < 0.05, 4 g vs. control, p < 0.05 (Fig. 5). This suggests lessening of interference from negative or neutral distractor words by the active treatment. Neither neuroticism nor aggression scores were significant covariates.Fig. 5


Effects of acute treatment with a tryptophan-rich protein hydrolysate on plasma amino acids, mood and emotional functioning in older women.

Gibson EL, Vargas K, Hogan E, Holmes A, Rogers PJ, Wittwer J, Kloek J, Goralczyk R, Mohajeri MH - Psychopharmacology (Berl.) (2014)

Effect of LumiVida™ on latencies to respond to positive target words (with negative or neutral distractor words; all trials). Both doses of LumiVida™ (hashed column = 2 g; solid column = 4 g) reduced the response latency, *p < 0.05 vs. control (open column). Means are adjusted for baseline performance, age and NART errors
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4231284&req=5

Fig5: Effect of LumiVida™ on latencies to respond to positive target words (with negative or neutral distractor words; all trials). Both doses of LumiVida™ (hashed column = 2 g; solid column = 4 g) reduced the response latency, *p < 0.05 vs. control (open column). Means are adjusted for baseline performance, age and NART errors
Mentions: It was predicted that participants would respond faster to positive words with negative or neutral distractors after LumiVida™ if the treatment reduced bias to negative stimuli. For both doses, LumiVida™ reduced the latency to respond to positive words, i.e. faster reactions, ANCOVA group effect, F(2, 53) = 3.05, p < 0.03 one tail, ηp2 = 0.10; contrasts, 2 g vs. control, p < 0.05, 4 g vs. control, p < 0.05 (Fig. 5). This suggests lessening of interference from negative or neutral distractor words by the active treatment. Neither neuroticism nor aggression scores were significant covariates.Fig. 5

Bottom Line: This treatment dose resulted in a significant shift in emotional processing towards positive words and reduced negative bias in assessing negative facial expressions.However, there was no evidence for any adverse effects.Consumption of a low dose of TRP-rich protein hydrolysate may have beneficial effects on emotional function that could promote feelings of wellbeing, possibly conferring resistance to deterioration in mood in healthy subjects or depressive episodes.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Whitelands College, University of Roehampton, Holybourne Avenue, London, SW15 4JD, UK, l.gibson@roehampton.ac.uk.

ABSTRACT

Rationale: Effective functioning of the neurotransmitter serotonin is important for optimal cognitive and emotional function. Dietary supplements able to increase availability to the brain of the precursor amino acid, tryptophan (TRP), and thereby enhance serotonin synthesis, can have measurable impact on these psychological processes.

Objectives: This study involves a randomised controlled trial of a TRP-rich egg-white protein hydrolysate (DSM Nutritional Products Ltd., Switzerland) on plasma amino acids, cognition, mood and emotional processing in older women.

Methods: Following a baseline test day without treatment, 60 healthy women aged 45-65 years received drinks containing either 2 or 4 g of TRP-rich protein hydrolysate product or 3.11 g casein hydrolysate as a control. One hour later, they undertook a 2-h battery of cognitive and emotional tests.

Results: The TRP-rich protein hydrolysate produced the expected dose-dependent increase in the ratio of plasma TRP to competing large neutral amino acids. TRP-rich protein hydrolysate (2 g only) prevented both the decline in wellbeing and increase in fatigue seen over the test session in the control group. This treatment dose resulted in a significant shift in emotional processing towards positive words and reduced negative bias in assessing negative facial expressions. Effects on cognition were small and not statistically reliable and are not reported here. However, there was no evidence for any adverse effects.

Conclusions: Consumption of a low dose of TRP-rich protein hydrolysate may have beneficial effects on emotional function that could promote feelings of wellbeing, possibly conferring resistance to deterioration in mood in healthy subjects or depressive episodes.

Show MeSH
Related in: MedlinePlus