Toll-like receptor expression in crypt epithelial cells, putative stem cells and intestinal myofibroblasts isolated from controls and patients with inflammatory bowel disease.
Bottom Line: In conclusion, enhanced TLR-2 and TLR-4 expression by crypt epithelial cells in active inflammatory bowel disease likely reflects greater ability to respond to microbial products.Results from our studies using mucosal samples from patients with distal ulcerative colitis suggest that the enhanced expression of these TLRs could be constitutive.TLR-2, TLR-4 and TLR-5 expression by stem cells imply ability to respond to distinct bacterial products.
Affiliation: Institute of Infection, Immunity and Inflammation, University of Nottingham, UK; Nottingham Digestive Diseases Centre, University of Nottingham, UK.Show MeSH
Related in: MedlinePlus
Mentions: There was significantly enhanced expression of TLR-4 transcripts in crypt cells isolated from inflamed ileal Crohn’s disease mucosal samples, when compared to cells obtained from normal control ileal tissue [fold increase: 1·84 (1·39–17·69), P = 0·030; Fig. 2a]. Although some Crohn’s ileal crypt cell samples showed high levels of TLR-2 mRNA expression, the difference between the two groups was not statistically significant [fold increase for Crohn’s group: 1·72 (0·23–3·89); Fig. 2b and Supporting information, Table S2].
Affiliation: Institute of Infection, Immunity and Inflammation, University of Nottingham, UK; Nottingham Digestive Diseases Centre, University of Nottingham, UK.