Phenotypic heterogeneity is a selected trait in natural yeast populations subject to environmental stress.
Bottom Line: We found that cell-to-cell heterogeneity (in resistance to the appropriate principal pollutant) was prevalent in the wild yeast isolates.Indeed, growth assays indicated that isolates with high heterogeneities had a significant competitive advantage during stress.The results showed that environmental stress selects for wild microorganisms with high levels of phenotypic heterogeneity.
Affiliation: School of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.Show MeSH
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Mentions: Considering Site 2, a total of 25 independent isolates of C. sake were collected from the control and Pb-polluted locations at this site. Similar to the trend seen at Site 1, the five least heterogeneous isolates from the control location were all less heterogeneous than any of the isolates from the polluted location (Fig. 3A). Accordingly, the mean heterogeneity was ∼ 42% lower for the control isolates, although the difference was not significant in this case (P = 0.0695). In contrast to heterogeneity, the mean IC50 across isolates from the polluted location was only marginally (< 2%) greater than that across isolates from the control location. The difference was not significant (P = 0.276) (Fig. 3B).
Affiliation: School of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.