Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts.
Bottom Line: Infarct size and cardiac function were measured by magnetic resonance imaging (MRI) 24 h after infarction.MitoSNO-treated mice exhibited reduced infarct size and preserved function.MitoSNO action acutely at reperfusion reduces infarct size and protects from post-myocardial infarction heart failure.
Affiliation: Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.Show MeSH
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Mentions: We first assessed whether this MitoSNO administration protocol protected against heart tissue damage measured by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 h post-reperfusion (Figure2A). This showed that a systemic i.v. bolus and infusion of MitoSNO beginning 5 min before reperfusion resulted in a significant reduction in infarct size (Figure2B) as well as significantly lower values of the clinically used marker, serum troponin I, 24 h post-MI in the MitoSNO-treated group (Figure2C).
Affiliation: Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.