Allelic association, DNA resequencing and copy number variation at the metabotropic glutamate receptor GRM7 gene locus in bipolar disorder.
Bottom Line: The three most significantly associated SNPs in the original UCL1 BP GWAS sample were genotyped in the UCL2 sample, of which none were associated.After combining the genotype data for the two samples only two (rs1508724 and rs6769814) of the original three SNP markers remained significantly associated with BP.A 3'-UTR SNP rs56173829 was found to be significantly associated with BP in the whole UCL sample (P = 0.035; OR = 0.482), the rare allele being less common in cases compared to controls.
Affiliation: Molecular Psychiatry Laboratory, Mental Health Sciences Unit, Faculty of Brain Sciences, University College London, London, UK.Show MeSH
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Mentions: McQuillin et al.  reported an analysis of copy number variants in the UCL1 bipolar research sample and found that the overall rate of CNVs was significantly lower in cases compared to controls. Both deletions and duplications of size >100 kb were detected in GRM7 in the UCL1 sample (Supplementary Table SVII). Deletions were present in two bipolar samples and one control sample and a duplication was found in only one case sample (Fig. 1).
Affiliation: Molecular Psychiatry Laboratory, Mental Health Sciences Unit, Faculty of Brain Sciences, University College London, London, UK.