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A study of antioxidant activity in patients with schizophrenia taking atypical antipsychotics.

Gilca M, Piriu G, Gaman L, Delia C, Iosif L, Atanasiu V, Stoian I - Psychopharmacology (Berl.) (2014)

Bottom Line: Atypical antipsychotics have significantly improved the quality of life for schizophrenic patients.Despite their beneficial effects, these antipsychotics induce weight gain, diabetes, and dyslipidemia.TEAC and GAP were only decreased in the clozapine-treated group.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, UMF Carol Davila, Bucharest, Romania.

ABSTRACT

Introduction: Atypical antipsychotics have significantly improved the quality of life for schizophrenic patients. Despite their beneficial effects, these antipsychotics induce weight gain, diabetes, and dyslipidemia. The aims of this study were to investigate the antioxidative activity of paraoxonase and assess lipid profile as a cardiovascular risk factor in patients with schizophrenia under long-term clozapine or risperidone treatment.

Methods: The study included 66 patients with schizophrenia under clozapine or risperidone treatment and 19 healthy control subjects. Serum paraoxonase activities against paraoxon (PON(PO)), phenylacetate (PON(PA)), dihydrocoumarin (PON(DHC)), serum Trolox equivalent antioxidant activity (TEAC), antioxidant gap (GAP), and lipid profile were determined.

Results: PON(DHC) activity was reduced in both antipsychotic drug-treated groups (clozapine 43.46 ± 1.06 U/ml, p < 0.001; risperidone 50.57 ± 1.54 U/ml, p < 0.01; control 52.27 ± 1.34 U/ml). A similar pattern was observed for the PON(DHC)/HDL-cholesterol (HDLC) ratio. On the contrary, PON(PO) and PON(PA) were increased in the treated group, but the corresponding paraoxonase/HDLC ratios were not significantly different from controls, except for PON/HDLC in the clozapine group. TEAC and GAP were only decreased in the clozapine-treated group.

Conclusions: In patients with schizophrenia, clozapine or risperidone treatment had different effects on various paraoxonase activities. The results of the present study suggest that patients with schizophrenia might be at increased risk for metabolic and cardiovascular disease related to reduced PON(DHC), TEAC, and GAP.

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Related in: MedlinePlus

TEAC and GAP values in clozapine- and risperidone-treated schizophrenic patients vs. the control group
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Fig3: TEAC and GAP values in clozapine- and risperidone-treated schizophrenic patients vs. the control group

Mentions: Data regarding oxidative stress-related parameters are shown in Figs. 1, 2, and 3. Paraoxonase activities against paraoxon as substrate (either basal or stimulated activity) were significantly higher in both groups of patients with schizophrenia than in control subjects (Fig. 1). The same variation was observed for PON(PA) (Fig. 2). Conversely, PON(DHC) was significantly lower in the two groups of patients than in the controls (Fig. 2).Fig. 1


A study of antioxidant activity in patients with schizophrenia taking atypical antipsychotics.

Gilca M, Piriu G, Gaman L, Delia C, Iosif L, Atanasiu V, Stoian I - Psychopharmacology (Berl.) (2014)

TEAC and GAP values in clozapine- and risperidone-treated schizophrenic patients vs. the control group
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4231214&req=5

Fig3: TEAC and GAP values in clozapine- and risperidone-treated schizophrenic patients vs. the control group
Mentions: Data regarding oxidative stress-related parameters are shown in Figs. 1, 2, and 3. Paraoxonase activities against paraoxon as substrate (either basal or stimulated activity) were significantly higher in both groups of patients with schizophrenia than in control subjects (Fig. 1). The same variation was observed for PON(PA) (Fig. 2). Conversely, PON(DHC) was significantly lower in the two groups of patients than in the controls (Fig. 2).Fig. 1

Bottom Line: Atypical antipsychotics have significantly improved the quality of life for schizophrenic patients.Despite their beneficial effects, these antipsychotics induce weight gain, diabetes, and dyslipidemia.TEAC and GAP were only decreased in the clozapine-treated group.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, UMF Carol Davila, Bucharest, Romania.

ABSTRACT

Introduction: Atypical antipsychotics have significantly improved the quality of life for schizophrenic patients. Despite their beneficial effects, these antipsychotics induce weight gain, diabetes, and dyslipidemia. The aims of this study were to investigate the antioxidative activity of paraoxonase and assess lipid profile as a cardiovascular risk factor in patients with schizophrenia under long-term clozapine or risperidone treatment.

Methods: The study included 66 patients with schizophrenia under clozapine or risperidone treatment and 19 healthy control subjects. Serum paraoxonase activities against paraoxon (PON(PO)), phenylacetate (PON(PA)), dihydrocoumarin (PON(DHC)), serum Trolox equivalent antioxidant activity (TEAC), antioxidant gap (GAP), and lipid profile were determined.

Results: PON(DHC) activity was reduced in both antipsychotic drug-treated groups (clozapine 43.46 ± 1.06 U/ml, p < 0.001; risperidone 50.57 ± 1.54 U/ml, p < 0.01; control 52.27 ± 1.34 U/ml). A similar pattern was observed for the PON(DHC)/HDL-cholesterol (HDLC) ratio. On the contrary, PON(PO) and PON(PA) were increased in the treated group, but the corresponding paraoxonase/HDLC ratios were not significantly different from controls, except for PON/HDLC in the clozapine group. TEAC and GAP were only decreased in the clozapine-treated group.

Conclusions: In patients with schizophrenia, clozapine or risperidone treatment had different effects on various paraoxonase activities. The results of the present study suggest that patients with schizophrenia might be at increased risk for metabolic and cardiovascular disease related to reduced PON(DHC), TEAC, and GAP.

Show MeSH
Related in: MedlinePlus