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Biomarkers of coronary artery disease: the promise of the transcriptome.

Siemelink MA, Zeller T - Curr Cardiol Rep (2014)

Bottom Line: The last years have witnessed tremendous technical advances in the field of transcriptomics that enable the simultaneous assessment of nearly all transcripts expressed in a tissue at a given time.These advances harbor the potential to gain a better understanding of the complex biological systems and for the identification and development of novel biomarkers.This article will review the current knowledge of transcriptomics biomarkers in the cardiovascular field and will provide an overview about the promises and challenges of the transcriptomics approach for biomarker identification.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaanes 100 Room G02.523, PO Box 85500, 3508 GA, Utrecht, The Netherlands, M.A.Siemelink@umcutrecht.nl.

ABSTRACT
The last years have witnessed tremendous technical advances in the field of transcriptomics that enable the simultaneous assessment of nearly all transcripts expressed in a tissue at a given time. These advances harbor the potential to gain a better understanding of the complex biological systems and for the identification and development of novel biomarkers. This article will review the current knowledge of transcriptomics biomarkers in the cardiovascular field and will provide an overview about the promises and challenges of the transcriptomics approach for biomarker identification.

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Challenges in transcriptomic biomarker development. Figure depicts main steps in Biomarker discovery and development and associated challenges to overcome
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Fig1: Challenges in transcriptomic biomarker development. Figure depicts main steps in Biomarker discovery and development and associated challenges to overcome

Mentions: Numerous excellent reports are published providing a comprehensive overview of pitfalls and challenges for biomarker discovery and translation, e.g., [55, 63–67]. Here, we briefly review the key challenging points (summarized in Fig. 1).Fig. 1


Biomarkers of coronary artery disease: the promise of the transcriptome.

Siemelink MA, Zeller T - Curr Cardiol Rep (2014)

Challenges in transcriptomic biomarker development. Figure depicts main steps in Biomarker discovery and development and associated challenges to overcome
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4231210&req=5

Fig1: Challenges in transcriptomic biomarker development. Figure depicts main steps in Biomarker discovery and development and associated challenges to overcome
Mentions: Numerous excellent reports are published providing a comprehensive overview of pitfalls and challenges for biomarker discovery and translation, e.g., [55, 63–67]. Here, we briefly review the key challenging points (summarized in Fig. 1).Fig. 1

Bottom Line: The last years have witnessed tremendous technical advances in the field of transcriptomics that enable the simultaneous assessment of nearly all transcripts expressed in a tissue at a given time.These advances harbor the potential to gain a better understanding of the complex biological systems and for the identification and development of novel biomarkers.This article will review the current knowledge of transcriptomics biomarkers in the cardiovascular field and will provide an overview about the promises and challenges of the transcriptomics approach for biomarker identification.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaanes 100 Room G02.523, PO Box 85500, 3508 GA, Utrecht, The Netherlands, M.A.Siemelink@umcutrecht.nl.

ABSTRACT
The last years have witnessed tremendous technical advances in the field of transcriptomics that enable the simultaneous assessment of nearly all transcripts expressed in a tissue at a given time. These advances harbor the potential to gain a better understanding of the complex biological systems and for the identification and development of novel biomarkers. This article will review the current knowledge of transcriptomics biomarkers in the cardiovascular field and will provide an overview about the promises and challenges of the transcriptomics approach for biomarker identification.

Show MeSH