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The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis.

Genua M, Rutella S, Correale C, Danese S - J Transl Med (2014)

Bottom Line: In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis.Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions.This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.

View Article: PubMed Central - PubMed

Affiliation: IBD Center, Humanitas Clinical and Research Hospital, Rozzano, Italy. marco.genua@humanitasresearch.it.

ABSTRACT
The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.

No MeSH data available.


Related in: MedlinePlus

TREM-1 and TREM-2 signaling. Overview of the main intracellular mediators activated by TREM-1 (A) and TREM-2 (B), in order to elicit downstream signaling. Depending on the cell-type involved, TREM-1 or TREM-2 ligation might activate different cytoplasmic adaptors, producing different outcomes.
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Fig2: TREM-1 and TREM-2 signaling. Overview of the main intracellular mediators activated by TREM-1 (A) and TREM-2 (B), in order to elicit downstream signaling. Depending on the cell-type involved, TREM-1 or TREM-2 ligation might activate different cytoplasmic adaptors, producing different outcomes.

Mentions: The use of cross-linked antibodies or fusion proteins has been the main strategy pursued to date to identify intracellular mediators and signaling cascades, activated either by TREM-1 or by TREM-2. In this work we will systematically review the main intracellular mediators and the principal outcomes directly linked to TREM-1 or TREM-2 activation, specifically focusing on the cell types involved in these responses (FigureĀ 2).Figure 2


The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis.

Genua M, Rutella S, Correale C, Danese S - J Transl Med (2014)

TREM-1 and TREM-2 signaling. Overview of the main intracellular mediators activated by TREM-1 (A) and TREM-2 (B), in order to elicit downstream signaling. Depending on the cell-type involved, TREM-1 or TREM-2 ligation might activate different cytoplasmic adaptors, producing different outcomes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4231187&req=5

Fig2: TREM-1 and TREM-2 signaling. Overview of the main intracellular mediators activated by TREM-1 (A) and TREM-2 (B), in order to elicit downstream signaling. Depending on the cell-type involved, TREM-1 or TREM-2 ligation might activate different cytoplasmic adaptors, producing different outcomes.
Mentions: The use of cross-linked antibodies or fusion proteins has been the main strategy pursued to date to identify intracellular mediators and signaling cascades, activated either by TREM-1 or by TREM-2. In this work we will systematically review the main intracellular mediators and the principal outcomes directly linked to TREM-1 or TREM-2 activation, specifically focusing on the cell types involved in these responses (FigureĀ 2).Figure 2

Bottom Line: In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis.Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions.This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.

View Article: PubMed Central - PubMed

Affiliation: IBD Center, Humanitas Clinical and Research Hospital, Rozzano, Italy. marco.genua@humanitasresearch.it.

ABSTRACT
The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.

No MeSH data available.


Related in: MedlinePlus