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Delineation of early and later adult onset depression by diffusion tensor imaging.

Cheng Y, Xu J, Yu H, Nie B, Li N, Luo C, Li H, Liu F, Bai Y, Shan B, Xu L, Xu X - PLoS ONE (2014)

Bottom Line: LO MDD was characterized by decreased FA, especially in the white matter (WM) of the fronto-occipital fasciculus and posterior limb of internal capsule, with a negative correlation with the severity of depressive symptoms; in marked contrast, EO MDD showed increased FA, especially in the WM of the corpus callosum, corticospinal midbrain and inferior fronto-occipital fasciculus, while FA of the WM near the midbrain had a positive correlation with the severity of depressive symptoms.LO MDD were delineated by an age of onset of 30 years old, as demonstrated by distinct abnormal FA clusters with opposite correlations with clinical symptoms.This DTI study supported the evidence of an exact age for the delineation of MDD, which could have broad multidisciplinary importance.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, PR China.

ABSTRACT

Background: Due to a lack of evidence, there is no consistent age of onset to define early onset (EO) versus later onset (LO) major depressive disorder (MDD). Fractional anisotropy (FA), derived from diffusion tensor imaging (DTI), has been widely used to study neuropsychiatric disorders by providing information about the brain circuitry, abnormalities of which might facilitate the delineation of EO versus LO MDD.

Method: In this study, 61 pairs of untreated, non-elderly, first-episode MDD patients and healthy controls (HCs) aged 18-45 years old received DTI scans. The voxel-based analysis method (VBM), classification analysis, using the Statistical Package for the Social Sciences (SPSS), and regression analyses were used to determine abnormal FA clusters and their correlations with age of onset and clinical symptoms.

Results: Classification analysis suggested in the best model that there were two subgroups of MDD patients, delineated by an age of onset of 30 years old, by which MDD patients could be divided into EO (18-29 years old) and LO (30-45 years old) groups. LO MDD was characterized by decreased FA, especially in the white matter (WM) of the fronto-occipital fasciculus and posterior limb of internal capsule, with a negative correlation with the severity of depressive symptoms; in marked contrast, EO MDD showed increased FA, especially in the WM of the corpus callosum, corticospinal midbrain and inferior fronto-occipital fasciculus, while FA of the WM near the midbrain had a positive correlation with the severity of depressive symptoms.

Conclusion: Specific abnormalities of the brain circuitry in EO vs. LO MDD were delineated by an age of onset of 30 years old, as demonstrated by distinct abnormal FA clusters with opposite correlations with clinical symptoms. This DTI study supported the evidence of an exact age for the delineation of MDD, which could have broad multidisciplinary importance.

Trial registration: ClinicalTrials.gov NCT00703742.

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Related in: MedlinePlus

FA clusters for EO vs. LO MDD.Upper panel (EO): Five clusters (a, c–f) with increased FA (red color) but one cluster (b) with decreased FA (blue color) was found in EO patients, compared with the paired HCs. Lower panel (LO): seven clusters (A–G), all with decreased FA (blue color), were found in LO patients compared with the paired HCs. EO, early onset; LO, later onset; MDD, major depressive disorder; HCs, healthy controls.
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pone-0112307-g002: FA clusters for EO vs. LO MDD.Upper panel (EO): Five clusters (a, c–f) with increased FA (red color) but one cluster (b) with decreased FA (blue color) was found in EO patients, compared with the paired HCs. Lower panel (LO): seven clusters (A–G), all with decreased FA (blue color), were found in LO patients compared with the paired HCs. EO, early onset; LO, later onset; MDD, major depressive disorder; HCs, healthy controls.

Mentions: In EO MDD patients, compared with their paired HCs, decreased FA values were found only in the left inferior longitudinal fasciculus (near the parahippocampal gyrus and superior temporal gyrus), wherever increased FA was identified in vast areas, including the bilateral corpus callosum (near the posterior cingulate gyrus), left inferior fronto-occipital fasciculus (superior occipital gyrus), right forceps major and optical radiation (cuneus, middle occipital gyrus) and right corticospinal midbrain (near the substantia nigra) (Figure 2; Table S3 in File S1).


Delineation of early and later adult onset depression by diffusion tensor imaging.

Cheng Y, Xu J, Yu H, Nie B, Li N, Luo C, Li H, Liu F, Bai Y, Shan B, Xu L, Xu X - PLoS ONE (2014)

FA clusters for EO vs. LO MDD.Upper panel (EO): Five clusters (a, c–f) with increased FA (red color) but one cluster (b) with decreased FA (blue color) was found in EO patients, compared with the paired HCs. Lower panel (LO): seven clusters (A–G), all with decreased FA (blue color), were found in LO patients compared with the paired HCs. EO, early onset; LO, later onset; MDD, major depressive disorder; HCs, healthy controls.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4231105&req=5

pone-0112307-g002: FA clusters for EO vs. LO MDD.Upper panel (EO): Five clusters (a, c–f) with increased FA (red color) but one cluster (b) with decreased FA (blue color) was found in EO patients, compared with the paired HCs. Lower panel (LO): seven clusters (A–G), all with decreased FA (blue color), were found in LO patients compared with the paired HCs. EO, early onset; LO, later onset; MDD, major depressive disorder; HCs, healthy controls.
Mentions: In EO MDD patients, compared with their paired HCs, decreased FA values were found only in the left inferior longitudinal fasciculus (near the parahippocampal gyrus and superior temporal gyrus), wherever increased FA was identified in vast areas, including the bilateral corpus callosum (near the posterior cingulate gyrus), left inferior fronto-occipital fasciculus (superior occipital gyrus), right forceps major and optical radiation (cuneus, middle occipital gyrus) and right corticospinal midbrain (near the substantia nigra) (Figure 2; Table S3 in File S1).

Bottom Line: LO MDD was characterized by decreased FA, especially in the white matter (WM) of the fronto-occipital fasciculus and posterior limb of internal capsule, with a negative correlation with the severity of depressive symptoms; in marked contrast, EO MDD showed increased FA, especially in the WM of the corpus callosum, corticospinal midbrain and inferior fronto-occipital fasciculus, while FA of the WM near the midbrain had a positive correlation with the severity of depressive symptoms.LO MDD were delineated by an age of onset of 30 years old, as demonstrated by distinct abnormal FA clusters with opposite correlations with clinical symptoms.This DTI study supported the evidence of an exact age for the delineation of MDD, which could have broad multidisciplinary importance.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, PR China.

ABSTRACT

Background: Due to a lack of evidence, there is no consistent age of onset to define early onset (EO) versus later onset (LO) major depressive disorder (MDD). Fractional anisotropy (FA), derived from diffusion tensor imaging (DTI), has been widely used to study neuropsychiatric disorders by providing information about the brain circuitry, abnormalities of which might facilitate the delineation of EO versus LO MDD.

Method: In this study, 61 pairs of untreated, non-elderly, first-episode MDD patients and healthy controls (HCs) aged 18-45 years old received DTI scans. The voxel-based analysis method (VBM), classification analysis, using the Statistical Package for the Social Sciences (SPSS), and regression analyses were used to determine abnormal FA clusters and their correlations with age of onset and clinical symptoms.

Results: Classification analysis suggested in the best model that there were two subgroups of MDD patients, delineated by an age of onset of 30 years old, by which MDD patients could be divided into EO (18-29 years old) and LO (30-45 years old) groups. LO MDD was characterized by decreased FA, especially in the white matter (WM) of the fronto-occipital fasciculus and posterior limb of internal capsule, with a negative correlation with the severity of depressive symptoms; in marked contrast, EO MDD showed increased FA, especially in the WM of the corpus callosum, corticospinal midbrain and inferior fronto-occipital fasciculus, while FA of the WM near the midbrain had a positive correlation with the severity of depressive symptoms.

Conclusion: Specific abnormalities of the brain circuitry in EO vs. LO MDD were delineated by an age of onset of 30 years old, as demonstrated by distinct abnormal FA clusters with opposite correlations with clinical symptoms. This DTI study supported the evidence of an exact age for the delineation of MDD, which could have broad multidisciplinary importance.

Trial registration: ClinicalTrials.gov NCT00703742.

Show MeSH
Related in: MedlinePlus