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Evaluation of the diagnostic performance of magnetic resonance spectroscopy in brain tumors: a systematic review and meta-analysis.

Wang W, Hu Y, Lu P, Li Y, Chen Y, Tian M, Yu L - PLoS ONE (2014)

Bottom Line: Stratified meta analysis showed higher sensitivity and specificity in child than adult.CSI had higher sensitivity and SV had higher specificity.Higher sensitivity and specificity were obtained in short TE value.

View Article: PubMed Central - PubMed

Affiliation: Center of PET/CT-MRI, Cancer Hospital of Harbin Medical University, Harbin, 150081, China.

ABSTRACT

Object: The aim of this study was to determine the suitability of magnetic resonance spectroscopy (MRS) for screening brain tumors, based on a systematic review and meta-analysis of published data on the diagnostic performance of MRS.

Methods: The PubMed and PHMC databases were systematically searched for relevant studies up to December 2013. The sensitivities and specificities of MRS in individual studies were calculated and the pooled diagnostic accuracies, with 95% confidence intervals (CI), were assessed under a fixed-effects model.

Results: Twenty-four studies were included, comprising a total of 1013 participants. Overall, no heterogeneity of diagnostic effects was observed between studies. The pooled sensitivity and specificity of MRS were 80.05% (95% CI = 75.97%-83.59%) and 78.46% (95% CI: 73.40%-82.78%), respectively. The area under the summary receiver operating characteristic curve was 0.78. Stratified meta analysis showed higher sensitivity and specificity in child than adult. CSI had higher sensitivity and SV had higher specificity. Higher sensitivity and specificity were obtained in short TE value.

Conclusion: Although the qualities of the studies included in the meta-analysis were moderate, current evidence suggests that MRS may be a valuable adjunct to magnetic resonance imaging for diagnosing brain tumors, but requires selection of suitable technique and TE value.

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Forest plot of estimate of diagnostic accuracy of LTE and STE stratified meta-analysis.
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pone-0112577-g007: Forest plot of estimate of diagnostic accuracy of LTE and STE stratified meta-analysis.

Mentions: In order to further detailed analyze the diagnostic power of MRS, we performed Stratified meat analysis based on the period of patients, MRS technique and TE value. Diagnostic power of MRS between adult and child showed that child had more high accuracy than adult (AUC 0.89 VS. 0.77, Figure 4A). Diagnostic performance of MRS showed both higher sensitivity (83.37% VS. 78.38%) and specificity (91.06% VS. 76.60%) in child (Figure 5). Our results limited the very few studies on child, that will be more accurate with the increase of the number of studies. Although AUC value of SV was higher than CSI (0.89 VS. 0.79, Figure 4B), CSI had higher sensitivity (82.39% VS. 79.35%) and SV had higher specificity (85.49% VS. 73.52%, Figure 6). Two techniques of MRS has its own advantage. Finally, we analyzed the diagnostic power of LTE and STE. STE showed slightly higher AUC (0.79 VS. 0.73, Figure 4C), and had higher sensitivity (88.40% VS. 80.23%) and specificity (77.86% VS. 73.52%, Figure 7). Although some studies adopted double standard including both LTE and STE, diagnostic power has not been improved (sensitivity = 80.05% [95% CI: 75.97%–83.59%] and specificity 78.46% [95% CI: 73.40%–82.78%], respectively).


Evaluation of the diagnostic performance of magnetic resonance spectroscopy in brain tumors: a systematic review and meta-analysis.

Wang W, Hu Y, Lu P, Li Y, Chen Y, Tian M, Yu L - PLoS ONE (2014)

Forest plot of estimate of diagnostic accuracy of LTE and STE stratified meta-analysis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4231038&req=5

pone-0112577-g007: Forest plot of estimate of diagnostic accuracy of LTE and STE stratified meta-analysis.
Mentions: In order to further detailed analyze the diagnostic power of MRS, we performed Stratified meat analysis based on the period of patients, MRS technique and TE value. Diagnostic power of MRS between adult and child showed that child had more high accuracy than adult (AUC 0.89 VS. 0.77, Figure 4A). Diagnostic performance of MRS showed both higher sensitivity (83.37% VS. 78.38%) and specificity (91.06% VS. 76.60%) in child (Figure 5). Our results limited the very few studies on child, that will be more accurate with the increase of the number of studies. Although AUC value of SV was higher than CSI (0.89 VS. 0.79, Figure 4B), CSI had higher sensitivity (82.39% VS. 79.35%) and SV had higher specificity (85.49% VS. 73.52%, Figure 6). Two techniques of MRS has its own advantage. Finally, we analyzed the diagnostic power of LTE and STE. STE showed slightly higher AUC (0.79 VS. 0.73, Figure 4C), and had higher sensitivity (88.40% VS. 80.23%) and specificity (77.86% VS. 73.52%, Figure 7). Although some studies adopted double standard including both LTE and STE, diagnostic power has not been improved (sensitivity = 80.05% [95% CI: 75.97%–83.59%] and specificity 78.46% [95% CI: 73.40%–82.78%], respectively).

Bottom Line: Stratified meta analysis showed higher sensitivity and specificity in child than adult.CSI had higher sensitivity and SV had higher specificity.Higher sensitivity and specificity were obtained in short TE value.

View Article: PubMed Central - PubMed

Affiliation: Center of PET/CT-MRI, Cancer Hospital of Harbin Medical University, Harbin, 150081, China.

ABSTRACT

Object: The aim of this study was to determine the suitability of magnetic resonance spectroscopy (MRS) for screening brain tumors, based on a systematic review and meta-analysis of published data on the diagnostic performance of MRS.

Methods: The PubMed and PHMC databases were systematically searched for relevant studies up to December 2013. The sensitivities and specificities of MRS in individual studies were calculated and the pooled diagnostic accuracies, with 95% confidence intervals (CI), were assessed under a fixed-effects model.

Results: Twenty-four studies were included, comprising a total of 1013 participants. Overall, no heterogeneity of diagnostic effects was observed between studies. The pooled sensitivity and specificity of MRS were 80.05% (95% CI = 75.97%-83.59%) and 78.46% (95% CI: 73.40%-82.78%), respectively. The area under the summary receiver operating characteristic curve was 0.78. Stratified meta analysis showed higher sensitivity and specificity in child than adult. CSI had higher sensitivity and SV had higher specificity. Higher sensitivity and specificity were obtained in short TE value.

Conclusion: Although the qualities of the studies included in the meta-analysis were moderate, current evidence suggests that MRS may be a valuable adjunct to magnetic resonance imaging for diagnosing brain tumors, but requires selection of suitable technique and TE value.

Show MeSH
Related in: MedlinePlus