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High variability in oral glucose tolerance among 1,128 patients with cystic fibrosis: a multicenter screening study.

Scheuing N, Holl RW, Dockter G, Hermann JM, Junge S, Koerner-Rettberg C, Naehrlich L, Smaczny C, Staab D, Thalhammer G, van Koningsbruggen-Rietschel S, Ballmann M - PLoS ONE (2014)

Bottom Line: However, no study provided within-patient coefficients of variation.All statistical analysis was implemented with SAS 9.4.Compared to the general population, variability of two hour blood glucose was 1.5 to 1.8-fold higher.

View Article: PubMed Central - PubMed

Affiliation: Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany.

ABSTRACT

Background: In cystic fibrosis, highly variable glucose tolerance is suspected. However, no study provided within-patient coefficients of variation. The main objective of this short report was to evaluate within-patient variability of oral glucose tolerance.

Methods: In total, 4,643 standardized oral glucose tolerance tests of 1,128 cystic fibrosis patients (median age at first test: 15.5 [11.5; 21.5] years, 48.8% females) were studied. Patients included were clinically stable, non-pregnant, and had at least two oral glucose tolerance tests, with no prior lung transplantation or systemic steroid therapy. Transition frequency from any one test to the subsequent test was analyzed and within-patient coefficients of variation were calculated for fasting and two hour blood glucose values. All statistical analysis was implemented with SAS 9.4.

Results: A diabetic glucose tolerance was confirmed in 41.2% by the subsequent test. A regression to normal glucose tolerance at the subsequent test was observed in 21.7% and to impaired fasting glucose, impaired glucose tolerance or both in 15.2%, 12.0% or 9.9%. The average within-patient coefficient of variation for fasting blood glucose was 11.1% and for two hour blood glucose 25.3%.

Conclusion: In the cystic fibrosis patients studied, a highly variable glucose tolerance was observed. Compared to the general population, variability of two hour blood glucose was 1.5 to 1.8-fold higher.

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Related in: MedlinePlus

Transition from any one test to a subsequent test.In total, 3,515 pairs of consecutive OGTTs are summarized. For each pair, the first test was categorized in one of the five glucose tolerance classes (NGT, IFG only, IGT only, IFG+IGT, DGT). The figure shows the percentage of subsequent test results for each glucose tolerance category. The number in parentheses indicates the number of OGTTs available for analysis. Abbreviations: NGT normal glucose tolerance, IFG impaired fasting glucose, IGT impaired glucose tolerance, DGT diabetic glucose tolerance, OGTT oral glucose tolerance test.
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pone-0112578-g002: Transition from any one test to a subsequent test.In total, 3,515 pairs of consecutive OGTTs are summarized. For each pair, the first test was categorized in one of the five glucose tolerance classes (NGT, IFG only, IGT only, IFG+IGT, DGT). The figure shows the percentage of subsequent test results for each glucose tolerance category. The number in parentheses indicates the number of OGTTs available for analysis. Abbreviations: NGT normal glucose tolerance, IFG impaired fasting glucose, IGT impaired glucose tolerance, DGT diabetic glucose tolerance, OGTT oral glucose tolerance test.

Mentions: Figure 2 displays the transition frequency from any one test to a subsequent test. For example, an OGTT in the DGT range was confirmed in 41.2% by the subsequent test.


High variability in oral glucose tolerance among 1,128 patients with cystic fibrosis: a multicenter screening study.

Scheuing N, Holl RW, Dockter G, Hermann JM, Junge S, Koerner-Rettberg C, Naehrlich L, Smaczny C, Staab D, Thalhammer G, van Koningsbruggen-Rietschel S, Ballmann M - PLoS ONE (2014)

Transition from any one test to a subsequent test.In total, 3,515 pairs of consecutive OGTTs are summarized. For each pair, the first test was categorized in one of the five glucose tolerance classes (NGT, IFG only, IGT only, IFG+IGT, DGT). The figure shows the percentage of subsequent test results for each glucose tolerance category. The number in parentheses indicates the number of OGTTs available for analysis. Abbreviations: NGT normal glucose tolerance, IFG impaired fasting glucose, IGT impaired glucose tolerance, DGT diabetic glucose tolerance, OGTT oral glucose tolerance test.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4231037&req=5

pone-0112578-g002: Transition from any one test to a subsequent test.In total, 3,515 pairs of consecutive OGTTs are summarized. For each pair, the first test was categorized in one of the five glucose tolerance classes (NGT, IFG only, IGT only, IFG+IGT, DGT). The figure shows the percentage of subsequent test results for each glucose tolerance category. The number in parentheses indicates the number of OGTTs available for analysis. Abbreviations: NGT normal glucose tolerance, IFG impaired fasting glucose, IGT impaired glucose tolerance, DGT diabetic glucose tolerance, OGTT oral glucose tolerance test.
Mentions: Figure 2 displays the transition frequency from any one test to a subsequent test. For example, an OGTT in the DGT range was confirmed in 41.2% by the subsequent test.

Bottom Line: However, no study provided within-patient coefficients of variation.All statistical analysis was implemented with SAS 9.4.Compared to the general population, variability of two hour blood glucose was 1.5 to 1.8-fold higher.

View Article: PubMed Central - PubMed

Affiliation: Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany.

ABSTRACT

Background: In cystic fibrosis, highly variable glucose tolerance is suspected. However, no study provided within-patient coefficients of variation. The main objective of this short report was to evaluate within-patient variability of oral glucose tolerance.

Methods: In total, 4,643 standardized oral glucose tolerance tests of 1,128 cystic fibrosis patients (median age at first test: 15.5 [11.5; 21.5] years, 48.8% females) were studied. Patients included were clinically stable, non-pregnant, and had at least two oral glucose tolerance tests, with no prior lung transplantation or systemic steroid therapy. Transition frequency from any one test to the subsequent test was analyzed and within-patient coefficients of variation were calculated for fasting and two hour blood glucose values. All statistical analysis was implemented with SAS 9.4.

Results: A diabetic glucose tolerance was confirmed in 41.2% by the subsequent test. A regression to normal glucose tolerance at the subsequent test was observed in 21.7% and to impaired fasting glucose, impaired glucose tolerance or both in 15.2%, 12.0% or 9.9%. The average within-patient coefficient of variation for fasting blood glucose was 11.1% and for two hour blood glucose 25.3%.

Conclusion: In the cystic fibrosis patients studied, a highly variable glucose tolerance was observed. Compared to the general population, variability of two hour blood glucose was 1.5 to 1.8-fold higher.

Show MeSH
Related in: MedlinePlus