Mast cell function: a new vision of an old cell.
Bottom Line: Mast cells have a widespread distribution and are found predominantly at the interface between the host and the external environment.Conversely, mast cell dysfunction has pointed to these cells as the main offenders in several chronic allergic/inflammatory disorders, cancer and autoimmune diseases.This review summarizes the current knowledge of mast cell function in both normal and pathological conditions with regards to their regulation, phenotype and role.
Affiliation: Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil (EZMDS, MCJ, CO).Show MeSH
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Mentions: The existence of a mast cell committed precursor (MCcp) has been described in mouse bone marrow. Using sequential immunomagnetic isolation with two mast cell-specific antibodies (mAb AA4 and mAb BGD6), Jamur and colleagues (Jamur et al. 2005) isolated and characterized a MCcp from the bone marrow of adult Balb/c mice (Fig. 2). This precursor cell was CD34+CD13+c-Kit+FcϵRI-, and contained mRNA for the α and β subunits of FcϵRI as well as for the mast cell-specific proteases mMCP-5, mMCP-7, and mouse carboxypeptidase A (CPA). Moreover, the MCcp gave rise only to mast cells in vitro and were able to reconstitute mast cells in lethally irradiated mice. Chen et al. (2005) also identified a putative MCcp in the bone marrow of C57BL/6 mice, which was Lin-, Sca-1-, c-Kit+, Ly6c-, FcϵRIα-, CD27-, β7+, and T1/ST2+, and gave rise only to mast cells in culture. These cells were able to reconstitute mast cells in KitW-sh/ KitW-sh mice. The authors also proposed the existence of a common precursor for mast cells and other myeloid cells within the multipotent progenitor population in the bone marrow (Chen et al. 2005).
Affiliation: Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil (EZMDS, MCJ, CO).