Synthesis of highly elastic biocompatible polyurethanes based on bio-based isosorbide and poly(tetramethylene glycol) and their properties.
Bottom Line: The test results showed that the poly(tetramethylene glycol)/isosorbide-based elastomer exhibited not only excellent stress-strain properties but also superior resilience to the existing polyether-based polyurethane elastomers.Degradation tests performed at 37℃ in phosphate buffer solution showed a mass loss of 4-9% after 8 weeks, except for the polyurethane with the lowest isosorbide content, which showed an initial rapid weight loss.These polyurethanes offer significant promise due to soft, flexible and biocompatible properties for soft tissue augmentation and regeneration.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.Show MeSH
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Mentions: The MC3T3-E1 cells were examined by SEM after they were cultured on the PU films for 1, 3, and 7 days. The SEM images of the MC3T3-E1 cell morphology after being cultured on PU film for 7 days are shown in Figure 9. The SEM micrographs revealed that the cell appeared to spread and occupy the PU film surface. In most areas, cell density appeared to be relatively high with close contact. Hence, these findings show that our PU films had no negative effect on cell attachment or proliferation. Proliferation was assessed by the MTS assay and revealed that our PUs were biocompatible and nontoxic. In addition, results of the MTS assay suggested that our composite scaffolds exhibited an appropriate environment for the loaded cells, which appeared to proliferate well during the cultivation periods. But viability of PU4 is less than 50% of the control at day 7. The low molecular weight or oligomeric product would act as a big variable in determining low viability of PU4.Figure 9.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.