Synthesis of highly elastic biocompatible polyurethanes based on bio-based isosorbide and poly(tetramethylene glycol) and their properties.
Bottom Line: The test results showed that the poly(tetramethylene glycol)/isosorbide-based elastomer exhibited not only excellent stress-strain properties but also superior resilience to the existing polyether-based polyurethane elastomers.Degradation tests performed at 37℃ in phosphate buffer solution showed a mass loss of 4-9% after 8 weeks, except for the polyurethane with the lowest isosorbide content, which showed an initial rapid weight loss.These polyurethanes offer significant promise due to soft, flexible and biocompatible properties for soft tissue augmentation and regeneration.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.Show MeSH
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Mentions: Cell attachment was examined with the MTS assay. The ODs at 450 nm for PU4 were 0.18, 0.25 and 0.32 after 1 -, 3 -, and 7-day cultures, indicating that the number of cells on the films had increased significantly. The results of CCK-8 absorbance values for MC3T3-E1 cells adhesion to and proliferation on the PU films compared to that of control are shown in Figure 8. It reflects not only the ability of the PU film to promote cell adhesion and proliferation, but also its cytotoxicity. Lower cell viability was observed from 1 to 7 days on the PU surfaces in comparison with that of the control.Figure 6.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.