Synthesis of highly elastic biocompatible polyurethanes based on bio-based isosorbide and poly(tetramethylene glycol) and their properties.
Bottom Line: The test results showed that the poly(tetramethylene glycol)/isosorbide-based elastomer exhibited not only excellent stress-strain properties but also superior resilience to the existing polyether-based polyurethane elastomers.Degradation tests performed at 37℃ in phosphate buffer solution showed a mass loss of 4-9% after 8 weeks, except for the polyurethane with the lowest isosorbide content, which showed an initial rapid weight loss.These polyurethanes offer significant promise due to soft, flexible and biocompatible properties for soft tissue augmentation and regeneration.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.Show MeSH
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Mentions: The degradation behavior of the PUs was examined in vitro. Samples were immersed in a phosphate buffer solution at 37℃. Figure 6 shows the percentage weight loss of the samples with time. Between weeks 0 and 1, PU1, PU2, and PU3 lost 2–3% of their weight, whereas PU4 showed a loss of about 4%. A continual slow weight loss was observed for PU1, PU2, and PU3 at the end of the test, and the final weight lost over 8 weeks was about 3%. However, the rate of PU4 weight loss was much faster than that of PU1, PU2, and PU3 over the 8 weeks, indicating that degradation of PUs with high molecular weight is slower than that of the low molecular weight PUs. In addition, the highly hydrophobic PU1 had a slower rate of water diffusion than those of the other PUs with higher isosorbide content. The surface of all polymers became rougher with time, although the extent of change differed depending on the composition of PUs tested. SEM photographs showed the changes in film surface after degradation. All surfaces initially appeared relatively smooth with few defects. However, the surface of all samples became rougher with time (Figure 7) and was significantly higher for PU4. The presence of isosorbide imparted a stronger hydrophilicity to the PU segment than did PTMG, which increased the rate of hydrolytic degradation.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.