Synthesis of highly elastic biocompatible polyurethanes based on bio-based isosorbide and poly(tetramethylene glycol) and their properties.
Bottom Line: The test results showed that the poly(tetramethylene glycol)/isosorbide-based elastomer exhibited not only excellent stress-strain properties but also superior resilience to the existing polyether-based polyurethane elastomers.Degradation tests performed at 37℃ in phosphate buffer solution showed a mass loss of 4-9% after 8 weeks, except for the polyurethane with the lowest isosorbide content, which showed an initial rapid weight loss.These polyurethanes offer significant promise due to soft, flexible and biocompatible properties for soft tissue augmentation and regeneration.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.Show MeSH
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Mentions: Figure 5 shows ultimate tensile strength, mean stiffness, and breaking strains for the PU samples. The PU films were flexible with ultimate tensile strengths (UTS) from 5.95 ± 0.35 MPa to 19.12 ± 1.25 MPa, mean stiffness (Young’s modulus) from 16.12 ± 0.64 MPa to 41.5 ± 2.12 MPa, and breaking strains from 153% to 1695% for PU1 and PU4, respectively. The UTS of the PU1 film was comparable to that of the aorta (50–100%),34 whereas the breaking strain was superior to that of the aorta. This is the first example of a high breaking strain of 1600% in an elastic biopolymer. Furthermore, the UTS value was retained at 19.12 ± 1.25 MPa at that point.Figure 5.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.