Synthesis of highly elastic biocompatible polyurethanes based on bio-based isosorbide and poly(tetramethylene glycol) and their properties.
Bottom Line: The test results showed that the poly(tetramethylene glycol)/isosorbide-based elastomer exhibited not only excellent stress-strain properties but also superior resilience to the existing polyether-based polyurethane elastomers.Degradation tests performed at 37℃ in phosphate buffer solution showed a mass loss of 4-9% after 8 weeks, except for the polyurethane with the lowest isosorbide content, which showed an initial rapid weight loss.These polyurethanes offer significant promise due to soft, flexible and biocompatible properties for soft tissue augmentation and regeneration.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.Show MeSH
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Mentions: The stability of the polymer films under physiological conditions is very important for biomedical applications, because an unstable polymer can induce undesirable or unexpected loss of biological function and activity of the biomaterials.22 For example, if the glass transition temperature (Tg) of the polymer is above that of body temperature, the polymer is in a rubbery state.23Table 2 shows the data collected from DSC measurements of the four PUs. The DSC analysis was conducted to characterize the thermal behaviors of the PUs. The endothermic transition at around 20℃ is melting transition of crystallized soft segments.24Tg was detected for all samples, as shown in Figure 4(a). The Tgs of PU1, PU2, PU3, and PU4 were −47.8, −45.8, −42.2, and −38.6℃, respectively, indicating that all PUs showed high elasticity even at low temperature. The resistance to heat of the PUs was examined by TGA, as shown in Figure 4(b). All PUs showed two-stage decomposition in the TGA thermograms, which was due to the existence of flexible alkylene and bicyclic units. It can be seen that the temperatures of 10% weight loss of the PUs decreased from 340℃ to 299℃ as isosorbide content increased, suggesting that all PUs were thermally stable and could tolerate sterilization.Figure 4.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.