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Synthesis of highly elastic biocompatible polyurethanes based on bio-based isosorbide and poly(tetramethylene glycol) and their properties.

Kim HJ, Kang MS, Knowles JC, Gong MS - J Biomater Appl (2014)

Bottom Line: The test results showed that the poly(tetramethylene glycol)/isosorbide-based elastomer exhibited not only excellent stress-strain properties but also superior resilience to the existing polyether-based polyurethane elastomers.Degradation tests performed at 37℃ in phosphate buffer solution showed a mass loss of 4-9% after 8 weeks, except for the polyurethane with the lowest isosorbide content, which showed an initial rapid weight loss.These polyurethanes offer significant promise due to soft, flexible and biocompatible properties for soft tissue augmentation and regeneration.

View Article: PubMed Central - PubMed

Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.

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Fourier transform-infrared (FT-IR) spectra of: (a) polyurethanes, isosorbide, PTMG and HDI; (b) C–H stretching; (c) C–O–C stretching bands of polyurethanes (PUs).
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fig2-0885328214533737: Fourier transform-infrared (FT-IR) spectra of: (a) polyurethanes, isosorbide, PTMG and HDI; (b) C–H stretching; (c) C–O–C stretching bands of polyurethanes (PUs).

Mentions: The FT-IR spectra of the PUs are shown in Figure 2(a). The PUs had a characteristic broad amide –NH– peak at 3325 cm−1 and strong carbonyl stretching absorption bands of amide at 1743 cm−1 and 1697 cm−1.31 Hydrogen bonded NH bending bands were seen at 1535 cm−1. Asymmetric and symmetric CH2 stretching bands were seen at 2936 cm−1 and 2852 cm−1, 1108 cm−1, respectively. The disappearance of –N = C = O stretching vibration around 2250 cm−1 suggested that there was no unreacted isocyanate groups in any of the PU samples.32 The IR spectra of PU1, PU2, PU3, and PU4 showed differences between the intensity of ethylene C–H stretching and ether combination absorption band around 2936 cm−1 and 2852 cm−1, and 1108 cm−1 indicating that the ratio of isosorbide to PTMG influenced the intensity of the C–H stretching band (Figure 2(b) and (c)).Figure 2.


Synthesis of highly elastic biocompatible polyurethanes based on bio-based isosorbide and poly(tetramethylene glycol) and their properties.

Kim HJ, Kang MS, Knowles JC, Gong MS - J Biomater Appl (2014)

Fourier transform-infrared (FT-IR) spectra of: (a) polyurethanes, isosorbide, PTMG and HDI; (b) C–H stretching; (c) C–O–C stretching bands of polyurethanes (PUs).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2 - License 3
Show All Figures
getmorefigures.php?uid=PMC4230967&req=5

fig2-0885328214533737: Fourier transform-infrared (FT-IR) spectra of: (a) polyurethanes, isosorbide, PTMG and HDI; (b) C–H stretching; (c) C–O–C stretching bands of polyurethanes (PUs).
Mentions: The FT-IR spectra of the PUs are shown in Figure 2(a). The PUs had a characteristic broad amide –NH– peak at 3325 cm−1 and strong carbonyl stretching absorption bands of amide at 1743 cm−1 and 1697 cm−1.31 Hydrogen bonded NH bending bands were seen at 1535 cm−1. Asymmetric and symmetric CH2 stretching bands were seen at 2936 cm−1 and 2852 cm−1, 1108 cm−1, respectively. The disappearance of –N = C = O stretching vibration around 2250 cm−1 suggested that there was no unreacted isocyanate groups in any of the PU samples.32 The IR spectra of PU1, PU2, PU3, and PU4 showed differences between the intensity of ethylene C–H stretching and ether combination absorption band around 2936 cm−1 and 2852 cm−1, and 1108 cm−1 indicating that the ratio of isosorbide to PTMG influenced the intensity of the C–H stretching band (Figure 2(b) and (c)).Figure 2.

Bottom Line: The test results showed that the poly(tetramethylene glycol)/isosorbide-based elastomer exhibited not only excellent stress-strain properties but also superior resilience to the existing polyether-based polyurethane elastomers.Degradation tests performed at 37℃ in phosphate buffer solution showed a mass loss of 4-9% after 8 weeks, except for the polyurethane with the lowest isosorbide content, which showed an initial rapid weight loss.These polyurethanes offer significant promise due to soft, flexible and biocompatible properties for soft tissue augmentation and regeneration.

View Article: PubMed Central - PubMed

Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.

Show MeSH
Related in: MedlinePlus