Synthesis of highly elastic biocompatible polyurethanes based on bio-based isosorbide and poly(tetramethylene glycol) and their properties.
Bottom Line: The test results showed that the poly(tetramethylene glycol)/isosorbide-based elastomer exhibited not only excellent stress-strain properties but also superior resilience to the existing polyether-based polyurethane elastomers.Degradation tests performed at 37℃ in phosphate buffer solution showed a mass loss of 4-9% after 8 weeks, except for the polyurethane with the lowest isosorbide content, which showed an initial rapid weight loss.These polyurethanes offer significant promise due to soft, flexible and biocompatible properties for soft tissue augmentation and regeneration.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.Show MeSH
Related in: MedlinePlus
License 1 - License 2 - License 3
Mentions: A family of aliphatic biodegradable and biocompatible PU elastomers based on hard segment isosorbide and soft segment PTMG were synthesized to design a number of implantable soft devices. The segmented PUs were composed of various ratios of soft segments to hard segments. Polymerization of HDI with various ratios of isorsorbide to PTMG was carried out by polyaddition-condensation at 120℃ for 12 h without catalyst, as shown in Figure 1. The ratios of isorsorbide to PTMG were 4:4, 5:3, 6:2, and 7:1. Bulk polymerization produced PUs of moderate molecular weight judging from the GPC data. The tough PU films were cast from a DMF solution.Figure 1.
Affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.