Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
Bottom Line: Vortioxetine was found to prevent the 5-HT-induced increase in inhibitory post-synaptic potentials recorded from CA1 pyramidal cells, most likely by 5-HT3 receptor antagonism.In comparison, the selective SERT inhibitor escitalopram showed no effect on any of these measures.Taken together, our results indicate that vortioxetine can increase pyramidal cell output, which leads to enhanced synaptic plasticity in the hippocampus.
Affiliation: Lundbeck Research USA, Paramus, NJ, USA EDAL@lundbeck.com.Show MeSH
Related in: MedlinePlus
License 1 - License 2 - License 3
Mentions: In contrast to vortioxetine, escitalopram did not inhibit the 5-HT-mediated increase in sIPSCs in any of the cells tested (Figure 3, n=6). In two of six cells, escitalopram slightly enhanced 5-HT-induced sIPSCs, but in the remaining four cells, there was no change in 5-HT response. Overall, escitalopram had no significant effect on the frequency and amplitude of 5-HT responses (Figures 3(a2) and 3(a3), p>0.05, paired Student’s t-test).
Affiliation: Lundbeck Research USA, Paramus, NJ, USA EDAL@lundbeck.com.