Limits...
Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.

Dale E, Zhang H, Leiser SC, Xiao Y, Lu D, Yang CR, Plath N, Sanchez C - J. Psychopharmacol. (Oxford) (2014)

Bottom Line: Vortioxetine was found to prevent the 5-HT-induced increase in inhibitory post-synaptic potentials recorded from CA1 pyramidal cells, most likely by 5-HT3 receptor antagonism.In comparison, the selective SERT inhibitor escitalopram showed no effect on any of these measures.Taken together, our results indicate that vortioxetine can increase pyramidal cell output, which leads to enhanced synaptic plasticity in the hippocampus.

View Article: PubMed Central - PubMed

Affiliation: Lundbeck Research USA, Paramus, NJ, USA EDAL@lundbeck.com.

Show MeSH

Related in: MedlinePlus

Escitalopram had no effect on serotonin (5-HT) increase of spontaneous inhibitory post-synaptic currents (sIPSCs). (a1) Representative sIPSCs recorded from a CA1 pyramidal neuron in response to 5-HT before (left) and after 15 min perfusion with 10 µM escitalopram (right). (a2), (a3) Escitalopram did not change the 5-HT response on sIPSC frequency (a2) or amplitude (a3) (p>0.05, paired Student’s t-test). Frequency and amplitude were normalized to the mean value during the 30 s of recordings prior to 5-HT application. Bar graphs represent the mean±standard error of the mean (SEM) from six cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2 - License 3
getmorefigures.php?uid=PMC4230848&req=5

fig3-0269881114543719: Escitalopram had no effect on serotonin (5-HT) increase of spontaneous inhibitory post-synaptic currents (sIPSCs). (a1) Representative sIPSCs recorded from a CA1 pyramidal neuron in response to 5-HT before (left) and after 15 min perfusion with 10 µM escitalopram (right). (a2), (a3) Escitalopram did not change the 5-HT response on sIPSC frequency (a2) or amplitude (a3) (p>0.05, paired Student’s t-test). Frequency and amplitude were normalized to the mean value during the 30 s of recordings prior to 5-HT application. Bar graphs represent the mean±standard error of the mean (SEM) from six cells.

Mentions: In contrast to vortioxetine, escitalopram did not inhibit the 5-HT-mediated increase in sIPSCs in any of the cells tested (Figure 3, n=6). In two of six cells, escitalopram slightly enhanced 5-HT-induced sIPSCs, but in the remaining four cells, there was no change in 5-HT response. Overall, escitalopram had no significant effect on the frequency and amplitude of 5-HT responses (Figures 3(a2) and 3(a3), p>0.05, paired Student’s t-test).


Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.

Dale E, Zhang H, Leiser SC, Xiao Y, Lu D, Yang CR, Plath N, Sanchez C - J. Psychopharmacol. (Oxford) (2014)

Escitalopram had no effect on serotonin (5-HT) increase of spontaneous inhibitory post-synaptic currents (sIPSCs). (a1) Representative sIPSCs recorded from a CA1 pyramidal neuron in response to 5-HT before (left) and after 15 min perfusion with 10 µM escitalopram (right). (a2), (a3) Escitalopram did not change the 5-HT response on sIPSC frequency (a2) or amplitude (a3) (p>0.05, paired Student’s t-test). Frequency and amplitude were normalized to the mean value during the 30 s of recordings prior to 5-HT application. Bar graphs represent the mean±standard error of the mean (SEM) from six cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2 - License 3
Show All Figures
getmorefigures.php?uid=PMC4230848&req=5

fig3-0269881114543719: Escitalopram had no effect on serotonin (5-HT) increase of spontaneous inhibitory post-synaptic currents (sIPSCs). (a1) Representative sIPSCs recorded from a CA1 pyramidal neuron in response to 5-HT before (left) and after 15 min perfusion with 10 µM escitalopram (right). (a2), (a3) Escitalopram did not change the 5-HT response on sIPSC frequency (a2) or amplitude (a3) (p>0.05, paired Student’s t-test). Frequency and amplitude were normalized to the mean value during the 30 s of recordings prior to 5-HT application. Bar graphs represent the mean±standard error of the mean (SEM) from six cells.
Mentions: In contrast to vortioxetine, escitalopram did not inhibit the 5-HT-mediated increase in sIPSCs in any of the cells tested (Figure 3, n=6). In two of six cells, escitalopram slightly enhanced 5-HT-induced sIPSCs, but in the remaining four cells, there was no change in 5-HT response. Overall, escitalopram had no significant effect on the frequency and amplitude of 5-HT responses (Figures 3(a2) and 3(a3), p>0.05, paired Student’s t-test).

Bottom Line: Vortioxetine was found to prevent the 5-HT-induced increase in inhibitory post-synaptic potentials recorded from CA1 pyramidal cells, most likely by 5-HT3 receptor antagonism.In comparison, the selective SERT inhibitor escitalopram showed no effect on any of these measures.Taken together, our results indicate that vortioxetine can increase pyramidal cell output, which leads to enhanced synaptic plasticity in the hippocampus.

View Article: PubMed Central - PubMed

Affiliation: Lundbeck Research USA, Paramus, NJ, USA EDAL@lundbeck.com.

Show MeSH
Related in: MedlinePlus