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Biological rhythm disturbance in remitted bipolar patients.

Rosa AR, Comes M, Torrent C, Solè B, Reinares M, Pachiarotti I, Salamero M, Kapczinski F, Colom F, Vieta E - Int J Bipolar Disord (2013)

Bottom Line: Bipolar patients (n = 107) experienced greater biological rhythm alterations than the control group (n = 100) (BRIAN total scores 35.36 ± 7.11 vs. 32.48 ± 6.10, t = 6.912, p = 0.002, Cohen's d = 0.43, r = 0.21).Furthermore, a significant correlation was found between biological rhythms with residual depressive symptoms (r = 0.459, p < 0.001) and functioning (r = 0.432, p < 0.001).These findings suggest a potential link between biological rhythms and the pathophysiology of bipolar disorder.

View Article: PubMed Central - PubMed

Affiliation: Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Villarroel 170, Barcelona, Catalonia, 08036 Spain ; Bipolar Disorders Program and INCT for Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre, Rio Grande do Sul 90035903 Brazil ; Centro Universitário La Salle, Rua Victor Barreto 2350, Canoas, Rio Grande do Sul 92010-000 Brazil.

ABSTRACT

Background: Biological rhythm disturbance is common in bipolar patients and seems to affect the course and prognosis of the illness negatively. The main aim of the current study was to assess biological rhythms in remitted bipolar patients. We also assessed whether there was an association between clinical variables or functioning and biological rhythms in remitted bipolar participants.

Methods: The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) was used to assess biological rhythm disturbance. It is an 18-item interviewer-administered instrument which allows us to investigate the main areas related to circadian rhythm disturbance (sleep/social, activities, and eating pattern) in bipolar disorder.

Results and discussion: Bipolar patients (n = 107) experienced greater biological rhythm alterations than the control group (n = 100) (BRIAN total scores 35.36 ± 7.11 vs. 32.48 ± 6.10, t = 6.912, p = 0.002, Cohen's d = 0.43, r = 0.21). In particular, patients were more impaired than the control group with regard to sleep/social (14.67 ± 4.14 vs. 13.49 ± 2.91, t = 10.61, p = 0.018, Cohen's d = 0.33, r = 0.16) and activity (8.49 ± 2.51 vs. 7.07 ± 2.13, t = 3.90, p = 0.001, Cohen's d = 0.61, r = 0.29) domains. Furthermore, a significant correlation was found between biological rhythms with residual depressive symptoms (r = 0.459, p < 0.001) and functioning (r = 0.432, p < 0.001). These findings suggest a potential link between biological rhythms and the pathophysiology of bipolar disorder. It highlights the importance of novel instruments (e.g., BRIAN) which allow us to assess biological rhythm disturbance in psychiatry. Finally, specific psychosocial interventions focused on lifestyle regularity may be considered as a supplemental treatment of bipolar illness episodes.

No MeSH data available.


Related in: MedlinePlus

Biological rhythm differences between patients and controls.
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Fig1: Biological rhythm differences between patients and controls.

Mentions: Forty-four percent of the patients were female with an overall mean age of 43 ± 14.35 years, and 27.8% of them had high education level. Demographic and clinical data of the sample are presented in Tables 1 and 2, respectively. Bipolar patients experienced greater overall biological rhythm disturbance than the control group (BRIAN total scores 35.36 ± 7.11 vs. 32.48 ± 6.10, t = 6.912, p = 0.002, Cohen's d = 0.43, r = 0.21). Specifically, the patients were more impaired than the control group with regard to sleep/social (14.67 ± 4.14 vs. 13.49 ± 2.91, t = 10.61, p = 0.018, Cohen's d = 0.33, r = 0.16) and activity domains of the BRIAN (8.49 ± 2.51 vs. 7.07 ± 2.13, t = 3.90, p < 0.001, Cohen's d = 0.61, r = 0.29). No differences between groups were found regarding eating pattern (6.15 ± 2.33 vs. 5.81 ± 2.10, t = 1.74, p = 0.274, Cohen's d = 0.15, r = 0.076; see Figure 1).Table 1


Biological rhythm disturbance in remitted bipolar patients.

Rosa AR, Comes M, Torrent C, Solè B, Reinares M, Pachiarotti I, Salamero M, Kapczinski F, Colom F, Vieta E - Int J Bipolar Disord (2013)

Biological rhythm differences between patients and controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230817&req=5

Fig1: Biological rhythm differences between patients and controls.
Mentions: Forty-four percent of the patients were female with an overall mean age of 43 ± 14.35 years, and 27.8% of them had high education level. Demographic and clinical data of the sample are presented in Tables 1 and 2, respectively. Bipolar patients experienced greater overall biological rhythm disturbance than the control group (BRIAN total scores 35.36 ± 7.11 vs. 32.48 ± 6.10, t = 6.912, p = 0.002, Cohen's d = 0.43, r = 0.21). Specifically, the patients were more impaired than the control group with regard to sleep/social (14.67 ± 4.14 vs. 13.49 ± 2.91, t = 10.61, p = 0.018, Cohen's d = 0.33, r = 0.16) and activity domains of the BRIAN (8.49 ± 2.51 vs. 7.07 ± 2.13, t = 3.90, p < 0.001, Cohen's d = 0.61, r = 0.29). No differences between groups were found regarding eating pattern (6.15 ± 2.33 vs. 5.81 ± 2.10, t = 1.74, p = 0.274, Cohen's d = 0.15, r = 0.076; see Figure 1).Table 1

Bottom Line: Bipolar patients (n = 107) experienced greater biological rhythm alterations than the control group (n = 100) (BRIAN total scores 35.36 ± 7.11 vs. 32.48 ± 6.10, t = 6.912, p = 0.002, Cohen's d = 0.43, r = 0.21).Furthermore, a significant correlation was found between biological rhythms with residual depressive symptoms (r = 0.459, p < 0.001) and functioning (r = 0.432, p < 0.001).These findings suggest a potential link between biological rhythms and the pathophysiology of bipolar disorder.

View Article: PubMed Central - PubMed

Affiliation: Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Villarroel 170, Barcelona, Catalonia, 08036 Spain ; Bipolar Disorders Program and INCT for Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre, Rio Grande do Sul 90035903 Brazil ; Centro Universitário La Salle, Rua Victor Barreto 2350, Canoas, Rio Grande do Sul 92010-000 Brazil.

ABSTRACT

Background: Biological rhythm disturbance is common in bipolar patients and seems to affect the course and prognosis of the illness negatively. The main aim of the current study was to assess biological rhythms in remitted bipolar patients. We also assessed whether there was an association between clinical variables or functioning and biological rhythms in remitted bipolar participants.

Methods: The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) was used to assess biological rhythm disturbance. It is an 18-item interviewer-administered instrument which allows us to investigate the main areas related to circadian rhythm disturbance (sleep/social, activities, and eating pattern) in bipolar disorder.

Results and discussion: Bipolar patients (n = 107) experienced greater biological rhythm alterations than the control group (n = 100) (BRIAN total scores 35.36 ± 7.11 vs. 32.48 ± 6.10, t = 6.912, p = 0.002, Cohen's d = 0.43, r = 0.21). In particular, patients were more impaired than the control group with regard to sleep/social (14.67 ± 4.14 vs. 13.49 ± 2.91, t = 10.61, p = 0.018, Cohen's d = 0.33, r = 0.16) and activity (8.49 ± 2.51 vs. 7.07 ± 2.13, t = 3.90, p = 0.001, Cohen's d = 0.61, r = 0.29) domains. Furthermore, a significant correlation was found between biological rhythms with residual depressive symptoms (r = 0.459, p < 0.001) and functioning (r = 0.432, p < 0.001). These findings suggest a potential link between biological rhythms and the pathophysiology of bipolar disorder. It highlights the importance of novel instruments (e.g., BRIAN) which allow us to assess biological rhythm disturbance in psychiatry. Finally, specific psychosocial interventions focused on lifestyle regularity may be considered as a supplemental treatment of bipolar illness episodes.

No MeSH data available.


Related in: MedlinePlus