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World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research.

Fassbender A, Rahmioglu N, Vitonis AF, Viganò P, Giudice LC, D'Hooghe TM, Hummelshoj L, Adamson GD, Becker CM, Missmer SA, Zondervan KT, WERF EPHect Working Gro - Fertil. Steril. (2014)

Bottom Line: We developed "recommended standard" and "minimum required" SOPs for the collection, processing, and storage of ectopic and eutopic endometrium, peritoneum, and myometrium, and a biospecimen data collection form necessary for interpretation of sample-derived results.The procedures are also relevant to research into other gynecologic conditions involving endometrium, myometrium, and peritoneum.The consensus SOPs are based on the best available evidence; areas with limited evidence are identified as requiring further pilot studies.

View Article: PubMed Central - PubMed

Affiliation: Organ Systems, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Department of Obstetrics and Gynecology, Leuven University Fertility Center, University Hospital Leuven, Leuven, Belgium.

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Related in: MedlinePlus

Flow diagram depicting the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) development and consensus process (tissue sample standard operating procedures (SOPs)).
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Related In: Results  -  Collection


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fig1: Flow diagram depicting the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) development and consensus process (tissue sample standard operating procedures (SOPs)).

Mentions: We conducted two workshops in March and July 2013, followed by several rounds of expert review, bringing together 54 leaders in endometriosis research and sample processing from 34 clinical/academic centers and three industry collaborators in 16 countries, to develop and reach consensus on evidence-based phenome collection and SOP guidelines (Fig. 1). During Workshop I and a subsequent consultation round, we identified 24 centers around the globe that collect tissues from endometriosis case and control subjects on a large scale (publication on >100 cases). We identified four tissue types (ectopic endometrium, eutopic endometrium, myometrium, and peritoneum) that were collected by the centers (Table 1); all provided SOPs for sample collection, processing, and storage.


World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research.

Fassbender A, Rahmioglu N, Vitonis AF, Viganò P, Giudice LC, D'Hooghe TM, Hummelshoj L, Adamson GD, Becker CM, Missmer SA, Zondervan KT, WERF EPHect Working Gro - Fertil. Steril. (2014)

Flow diagram depicting the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) development and consensus process (tissue sample standard operating procedures (SOPs)).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4230778&req=5

fig1: Flow diagram depicting the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) development and consensus process (tissue sample standard operating procedures (SOPs)).
Mentions: We conducted two workshops in March and July 2013, followed by several rounds of expert review, bringing together 54 leaders in endometriosis research and sample processing from 34 clinical/academic centers and three industry collaborators in 16 countries, to develop and reach consensus on evidence-based phenome collection and SOP guidelines (Fig. 1). During Workshop I and a subsequent consultation round, we identified 24 centers around the globe that collect tissues from endometriosis case and control subjects on a large scale (publication on >100 cases). We identified four tissue types (ectopic endometrium, eutopic endometrium, myometrium, and peritoneum) that were collected by the centers (Table 1); all provided SOPs for sample collection, processing, and storage.

Bottom Line: We developed "recommended standard" and "minimum required" SOPs for the collection, processing, and storage of ectopic and eutopic endometrium, peritoneum, and myometrium, and a biospecimen data collection form necessary for interpretation of sample-derived results.The procedures are also relevant to research into other gynecologic conditions involving endometrium, myometrium, and peritoneum.The consensus SOPs are based on the best available evidence; areas with limited evidence are identified as requiring further pilot studies.

View Article: PubMed Central - PubMed

Affiliation: Organ Systems, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Department of Obstetrics and Gynecology, Leuven University Fertility Center, University Hospital Leuven, Leuven, Belgium.

Show MeSH
Related in: MedlinePlus