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World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research.

Becker CM, Laufer MR, Stratton P, Hummelshoj L, Missmer SA, Zondervan KT, Adamson GD, WERF EPHect Working Gro - Fertil. Steril. (2014)

Bottom Line: An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries.A postsurgical scoring sheet containing general and gynecological patient and procedural information, extent of disease, the location and type of endometriotic lesion, and any other findings was developed during several rounds of review.This is the first multicenter, international collaboration between academic centers and industry addressing standardization of phenotypic data collection for a specific disease.

View Article: PubMed Central - PubMed

Affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom; Endometriosis CaRe Centre Oxford, University of Oxford, Oxford, United Kingdom. Electronic address: christian.becker@obs-gyn.ox.ac.uk.

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Suggested timeline for biological sample collection depending on research question.
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Related In: Results  -  Collection


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fig3: Suggested timeline for biological sample collection depending on research question.

Mentions: In general, sampling should be performed as early as possible to diminish a possible impact of anesthetic drugs and the above-mentioned confounding variables on results (37). Provided it is clinically justifiable, the order of sampling is dictated by the research question (Fig. 3). For example, if intra-abdominal sampling (peritoneum, peritoneal fluid, endometriotic disease) is the main focus, it is recommended to perform laparoscopy before hysteroscopy to avoid contamination from hysteroscopic fluid. However, it may be clinically indicated to start the operation with the hysteroscopy. For research purposes, the order of surgical procedures and the type of the hysteroscopic fluid should be recorded as indicated on the EPHect SSF.


World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research.

Becker CM, Laufer MR, Stratton P, Hummelshoj L, Missmer SA, Zondervan KT, Adamson GD, WERF EPHect Working Gro - Fertil. Steril. (2014)

Suggested timeline for biological sample collection depending on research question.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4230690&req=5

fig3: Suggested timeline for biological sample collection depending on research question.
Mentions: In general, sampling should be performed as early as possible to diminish a possible impact of anesthetic drugs and the above-mentioned confounding variables on results (37). Provided it is clinically justifiable, the order of sampling is dictated by the research question (Fig. 3). For example, if intra-abdominal sampling (peritoneum, peritoneal fluid, endometriotic disease) is the main focus, it is recommended to perform laparoscopy before hysteroscopy to avoid contamination from hysteroscopic fluid. However, it may be clinically indicated to start the operation with the hysteroscopy. For research purposes, the order of surgical procedures and the type of the hysteroscopic fluid should be recorded as indicated on the EPHect SSF.

Bottom Line: An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries.A postsurgical scoring sheet containing general and gynecological patient and procedural information, extent of disease, the location and type of endometriotic lesion, and any other findings was developed during several rounds of review.This is the first multicenter, international collaboration between academic centers and industry addressing standardization of phenotypic data collection for a specific disease.

View Article: PubMed Central - PubMed

Affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom; Endometriosis CaRe Centre Oxford, University of Oxford, Oxford, United Kingdom. Electronic address: christian.becker@obs-gyn.ox.ac.uk.

Show MeSH
Related in: MedlinePlus